PMID: 2113909Jul 1, 1990Paper

Identification of cis-acting sequences required for translational autoregulation of the ermC methylase

Journal of Bacteriology
F Breidt, D Dubnau

Abstract

ermC methylase gene expression has been shown to be limited by translational autorepression, presumably due to methylase binding to ermC mRNA. It was found that this repression occurs in trans, yielding a 50% reduction in translation of an ermC-lacZ fusion mRNA. We investigated the ermC mRNA sequences required for translational repression in vivo. A series of deletions identified sequences in the 5' regulatory region that were required for translational repression. These included sequences of the 5' stem-loop structure that were not required for induction, as well as some that were required. The implications of these results for regulation are discussed.

References

Nov 24, 1979·Nucleic Acids Research·H C Birnboim, J Doly
Aug 1, 1987·Journal of Bacteriology·C D Denoya, D Dubnau
Oct 1, 1989·Journal of Bacteriology·M AlbanoD A Dubnau
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D H Bechhofer, D Dubnau
Jul 1, 1987·Journal of Bacteriology·M AlbanoD Dubnau
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T A Kunkel
May 1, 1973·Journal of Bacteriology·J N ReeveR M Cole
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A G ShivakumarD Dubnau
Jan 1, 1984·Annual Review of Biochemistry·M NomuraG Baughman
Jan 1, 1982·Molecular & General Genetics : MGG·J HahnD Dubnau
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S Horinouchi, B Weisblum

❮ Previous
Next ❯

Citations

Sep 1, 1990·Molecular Microbiology·D H Bechhofer
Jun 10, 2003·Microbiology and Molecular Biology Reviews : MMBR·Ciarán Condon
Jun 13, 1998·Antimicrobial Agents and Chemotherapy·A RosatoR Leclercq
Apr 1, 1996·Journal of Bacteriology·W Wang, D H Bechhofer
Sep 1, 1996·Journal of Bacteriology·M KojicB Vasiljevic
Apr 1, 1995·Antimicrobial Agents and Chemotherapy·B Weisblum
Jun 1, 1995·Journal of Bacteriology·K K HueD H Bechhofer
Jul 1, 1991·Antimicrobial Agents and Chemotherapy·R Leclercq, P Courvalin
Jun 1, 1991·Journal of Bacteriology·K K Hue, D H Bechhofer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
D H Bechhofer, D Dubnau
Molecular Microbiology
J F DiMari, D H Bechhofer
Molecular & General Genetics : MGG
J HahnD Dubnau
© 2021 Meta ULC. All rights reserved