Identification of coeliac disease in primary care

Scandinavian Journal of Gastroenterology
W DickeyD F Hughes

Abstract

Coeliac disease is common yet often undiagnosed because symptoms may be trivial, non-specific, or non-gastrointestinal, or because of lack of clinician awareness. Serum IgA-class endomysial antibodies (EmA) have high specificity for coeliac disease and may facilitate case-finding by clinicians other than gastroenterologists. We assessed the appropriateness and diagnostic yield of of requests for EmA by primary care general practitioners in a defined geographic area of Northern Ireland. We identified patients who had EmA examination requests by their general practitioners during 1994-1996. Individual patient questionnaires were posted to the general practitioners concerned, seeking information on indications for testing, management after the result, and final diagnosis. We compared new patient diagnosis rates in two catchment areas, one served by a large district general hospital with, and the other by smaller hospitals without, a medical gastroenterology facility. A total of 239 patients had coeliac profile testing by 69 of 177 general practitioners in the area. Data were available for 181 patients not previously known to have coeliac disease, of whom 20 (11%) had EmA. All EmA-positive patients were referred to hospital, where ...Continue Reading

References

Nov 8, 1980·British Medical Journal·C M Swinson, A J Levi
Jan 22, 1994·Lancet·C CatassiP L Giorgi
Mar 1, 1996·Gut·T ValdimarssonM Ström
Jul 1, 1996·Journal of Clinical Gastroenterology·W Dickey, J B McConnell
Jan 1, 1996·Scandinavian Journal of Gastroenterology·H AscherH Tlaskalová

❮ Previous
Next ❯

Citations

Aug 28, 2002·Gastrointestinal Endoscopy·Gregory OldsMichael V Sivak
Oct 6, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·W Dickey, S A McMillan
Dec 27, 2005·Pathologie-biologie·A MankaïI Ghedira
Feb 4, 1999·Scandinavian Journal of Gastroenterology·K L KolhoE Savilahti
Nov 21, 2001·The Journal of Clinical Investigation·D LeslieA L Notkins
Mar 16, 2007·The American Journal of Gastroenterology·Carlo CatassiAlessio Fasano
Aug 19, 2007·Clinical Chemistry·Kelly E McGowanJ Decker Butzner
Mar 31, 2004·The American Journal of Clinical Nutrition·Joseph A MurrayFrank Mitros

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Related Papers

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
W Dickey, S A McMillan
Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
I BertiA Ventura
© 2022 Meta ULC. All rights reserved