Identification of collagen-induced arthritis loci in aged multiparous female mice

Arthritis Research & Therapy
Maria LiljanderR Mattsson

Abstract

Collagen-induced arthritis in mice is one of the most commonly used autoimmune experimental models, with many similarities to rheumatoid arthritis. Since collagen-induced arthritis is a complex polygenic disease there is a need for identification of several major disease-controlling genes. Because rheumatoid arthritis particularly affects aged women, we have in the present study identified new genetic regions critical for collagen-induced arthritis by studying aged female mice of a cross between NFR/N and B10.Q (H-2q haplotype). The mice in the present study had different reproductive histories, which did not significantly affect the onset, incidence or severity of the disease. A total of 200 female mice were used in a total genome-wide screening with 125 microsatellite markers. We found one new significant quantitative trait locus affecting the arthritis incidence, severity and day of onset on chromosome 11 (denoted Cia40), which colocalizes with a locus controlling pregnancy failure. Furthermore, a quantitative trait locus of suggestive significance associated with the incidence, severity and day of onset was identified on chromosome 1. Finally, a suggestively significant quantitative trait locus associated with collagen type...Continue Reading

References

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Citations

Jan 1, 2009·Arthritis Research & Therapy·Therese LindvallAsa Andersson
Sep 4, 2007·Rheumatology International·Kalaivani GanesanRengarajulu Puvanakrishnan
Dec 20, 2012·Clinical & Developmental Immunology·Timea BesenyeiZoltan Szekanecz
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xinhua YuSaleh M Ibrahim
Jan 13, 2021·Biochemical Pharmacology·Minghao ChenLing Ye

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Methods Mentioned

BETA
genotyping
biopsies
PCR
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Software Mentioned

Map Manager QTXb20

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