Identification of Compound-B, a novel anti-dengue virus agent targeting the non-structural protein 4A

Antiviral Research
Haruaki NoboriAkihiko Sato

Abstract

Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic fever/dengue shock syndrome. At present, no antiviral drugs are available for treatment DENV infections. In this study, a screening system based on a DENV-infected cell-based assay identified a novel anti-DENV agent with a benzimidazole skeleton, named Compound-B, which demonstrated antiviral activity specific to four DENV serotypes (EC50: 1.32-4.12 μM). Analysis of a single amino acid substitution of Compound-B-resistant DENV2 revealed that mutation C87S in the non-structural protein 4A (NS4A) contributes to resistance to Compound-B.

Citations

Oct 23, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Takao SanakiAkihiko Sato
Dec 2, 2020·The American Journal of Tropical Medicine and Hygiene·Steven D Langerman, Mija Ververs
Jan 23, 2021·RSC Medicinal Chemistry·Fumiaki Yokokawa
Jan 1, 2019·Antiviral Research·Siew Pheng Lim

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