Identification of core aberrantly expressed microRNAs in serous ovarian carcinoma

Oncotarget
Steven F ChenYate-Ching Yuan

Abstract

MicroRNAs (miRNAs) have recently demonstrated great potential and enormous promise in the diagnosis, prognosis and therapy of various types of cancer. In this study, we performed a comprehensive miRNA expression analysis in the omental metastasis of serous ovarian carcinoma (SOC) using small RNA sequencing. Two hundred and fifty-one aberrantly expressed miRNAs were identified, which clearly separated malignant omentum from normal omentum. Furthermore, miRNA profiles in primary chemo-sensitive and chemo-resistant/refractory SOC were determined using publicly available data. Comparing miRNA expression profiles in omental metastases and primary chemo-sensitive and chemo-resistant/refractory tumors, a set of 70 miRNAs that were aberrantly expressed in both primary and metastatic SOC has been identified for the first time. These core aberrantly expressed miRNAs may play crucial roles in the tumorigenesis, growth, and metastasis of SOC. Therefore, they can serve as potential diagnostic biomarkers and as therapeutic targets for miRNA-mediated therapy. Kaplan-Meier overall survival analysis using The Cancer Genome Atlas data demonstrated that 10 miRNAs (hsa-miR-135, 150, -340, 625, 1908, 3187, -96, -196b, -449c, and -1275) were associa...Continue Reading

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Citations

Sep 12, 2019·Scientific Reports·Sirisha ThippabhotlaMei He
Oct 2, 2019·International Journal of Molecular Sciences·Eros AzzaliniSerena Bonin
Oct 20, 2018·Expert Review of Molecular Diagnostics·Konstantina PanoutsopoulouAndreas Scorilas
Oct 15, 2019·Frontiers in Cell and Developmental Biology·Alka SinghManisha Sachan
May 27, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raju KandimallaAjay Goel
Aug 7, 2021·Biomolecules·Chao-Lien LiuTsui-Lien Mao

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Methods Mentioned

BETA
PCR

Software Mentioned

ENSEMBL
CASAVA
Ingenuity Pathway Analysis and
miRbase
TRANSFAC
cutadapt
CLC Bio
Partek
Survival package
Biomedical Genomics Workbench

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