Identification of COVID-19 Infection-Related Human Genes Based on a Random Walk Model in a Virus-Human Protein Interaction Network

BioMed Research International
YuHang ZhangYu-Dong Cai

Abstract

Coronaviruses are specific crown-shaped viruses that were first identified in the 1960s, and three typical examples of the most recent coronavirus disease outbreaks include severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and COVID-19. Particularly, COVID-19 is currently causing a worldwide pandemic, threatening the health of human beings globally. The identification of viral pathogenic mechanisms is important for further developing effective drugs and targeted clinical treatment methods. The delayed revelation of viral infectious mechanisms is currently one of the technical obstacles in the prevention and treatment of infectious diseases. In this study, we proposed a random walk model to identify the potential pathological mechanisms of COVID-19 on a virus-human protein interaction network, and we effectively identified a group of proteins that have already been determined to be potentially important for COVID-19 infection and for similar SARS infections, which help further developing drugs and targeted therapeutic methods against COVID-19. Moreover, we constructed a standard computational workflow for predicting the pathological biomarkers and related pharmacological targets of infectious dis...Continue Reading

References

Apr 1, 1978·The Journal of General Virology·G A Tannock, J C Hierholzer
Jan 1, 1983·The Journal of General Virology·B W MahyV ter Meulen
Dec 11, 1999·Nucleic Acids Research·I XenariosD Eisenberg
Oct 8, 2004·Journal of Biochemistry and Molecular Biology·Abdulaziz Ali A Al-Khedhairy
Nov 30, 2004·Virus Research·Mamadi YillaLarry J Anderson
Jan 22, 2005·Annual Review of Medicine·Danuta M SkowronskiLorne Babiuk
Jan 22, 2005·Respiratory Research·David A GronebergPeter Zabel
Dec 31, 2005·Nucleic Acids Research·Chris StarkMike Tyers
Jan 18, 2006·Nature Reviews. Microbiology·Cornelia C BergmannStephen A Stohlman
Jun 9, 2006·The Journal of General Virology·Sougata SahaPundi N Rangarajan
Sep 14, 2006·PLoS Medicine·Lauren J StockmanPaul Garner
Mar 1, 2007·Emerging Infectious Diseases·Lin-Fa WangBryan T Eaton
Apr 25, 2007·Virus Research·Zhengli Shi, Zhihong Hu
Mar 29, 2008·American Journal of Human Genetics·Sebastian KöhlerPeter N Robinson
Nov 4, 2010·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Sep 3, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hisham MomattinJaffar A Al-Tawfiq
Aug 28, 2014·The New England Journal of Medicine·Christian DrostenZiad A Memish
Nov 28, 2014·Nucleic Acids Research·UNKNOWN Gene Ontology Consortium
Dec 8, 2014·Molecular Immunology·Saeeda MunirÅsa Torinsson Naluai
Oct 21, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yudong Yin, Richard G Wunderink
Dec 5, 2017·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Fei Yuan, WenCong Lu
Dec 17, 2017·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Lei ChenXian Zhao
May 3, 2018·BMC Public Health·Ji-Eun ParkJi-Eun Park
Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
May 27, 2020·Computational and Mathematical Methods in Medicine·Haiyan LiangXiaolin Zhang

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Datasets Mentioned

BETA
MN908947

Software Mentioned

Search Tool for the
InterPro
STRING

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.