PMID: 8959246Dec 10, 1996Paper

Identification of cross-reactive antigenic target regions for HIV type 1-specific antibody-dependent cellular cytotoxicity

AIDS Research and Human Retroviruses
K BrolidenA Vahlne

Abstract

Monkey-derived hyperimmune antisera against 40 peptides, together representing the entire envelope gp120 of HIV-1LAI, were used to map antibody-dependent cellular cytotoxicity (ADCC) target regions. Four regions corresponding to amino acids 65-126, 152-230, 248-330, and 445-466 were found to contain epitopes inducing ADCC activity not only against HIV-1LAI-infected cells but also against cells infected with HIV-1SF2 and clinical isolates of HIV-1. When comparing seroreactivity to the individual peptides with ADCC titers none of the regions seemed to be dominant. These results thus describe cross-reactive regions involved in the functional immunity against HIV-1 gp120.

References

Jan 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·P A BrolidenK Broliden
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·T J PalkerB F Haynes
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J R RuscheP J Fischinger
Jan 1, 1987·AIDS Research and Human Retroviruses·H K LyerlyK J Weinhold
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H K LyerlyK J Weinhold

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Citations

Jul 8, 2011·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Justin PollaraGuido Ferrari

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