PMID: 9419775Jul 1, 1994Paper

Identification of cyclo(His-Pro)-like immunoreactivity in human follicular fluid: correlation with steroid and peptide hormones

Journal of the Society for Gynecologic Investigation
G C WolfC W Hilton

Abstract

The purpose of this study was to evaluate human follicular fluid (FF) for the presence of cyclo(His-Pro)-like immunoreactivity (CHP-LI). After verifying its presence, we quantitated the levels and investigated correlations with other follicular parameters, including hormone levels. Follicular fluid was collected from female volunteers undergoing controlled ovarian hyperstimulation. Fluid was collected by follicular puncture, either transvaginally (in vitro fertilization) or laparoscopically (gamete intrafallopian transfer) at the time of oocyte retrieval (N = 137). Follicular size was determined ultrasonographically. Assays for steroid and peptide hormones were determined with commercially available radioimmunoassay kits. CHP-LI was measured using a previously reported assay; parallel dilution curves and column chromatography aided in immunoidentity. The mean FF CHP-LI concentration (13.10 +/- 1.83 nmol/L, N = 137) was greater than the corresponding serum values (9.42 +/- 2.45 nmol/L; N = 21) (P < .05). Large follicles (20 mm or greater; 14.45 +/- 1.74 nmol/L) contained significantly more CHP-LI than either medium follicles (16-19 mm; 11.51 +/- 1.88 nmol/L) or small follicles (15 mm or smaller; 10.83 +/- 2.12 nmol/L) (P < .05)....Continue Reading

References

Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·E VanlucheneD Vandekerckhove
Jan 1, 1989·Annals of the New York Academy of Sciences·C Prasad
Mar 1, 1985·The Journal of Clinical Endocrinology and Metabolism·R FormanE Walters
Mar 1, 1984·The Journal of Clinical Endocrinology and Metabolism·N LauferH R Behrman
May 1, 1982·The Journal of Clinical Endocrinology and Metabolism·A KauppilaP Ylöstalo
Sep 1, 1992·Trends in Endocrinology and Metabolism : TEM·E Y Adashi, R M Rohan

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