Identification of CYP genes in Mytilus (mussel) and Crassostrea (oyster) species: first approach to the full complement of cytochrome P450 genes in bivalves.

Marine Environmental Research
Juliano ZanetteJohn J Stegeman

Abstract

Understanding the fate and effects of organic chemicals in animals requires knowledge of cytochrome P450 (CYP) genes, which thus far are poorly known in bivalve mollusks. We searched for CYP sequences in EST databases for Mytilus and Crassostrea species, lophotrochozoan representatives of the protostomes. From ESTs averaging ca. 924bp, we identified 58 CYP genes in Mytilus californianus and 39 CYP genes in Crassostrea gigas. The sequences fell in all known animal CYP clans, and collectively they clustered in phylogenetic analysis with vertebrate CYP families 1, 2, 3, 4, 17, 20, 26 and 27. As in deuterostomes, a majority of the sequences fell in Clan 2. The CYP sequences found thus far in bivalves suggest a diversity consistent with that found in many other animal species. The present description of mollusk genes provides the overall framework for classification of any additional bivalve sequences. The sequences identified also will be useful in obtaining full-length sequences and in designing primers for analysis of expression of mussel and oyster CYP genes, or for recombinant protein expression to identify potential substrates for the bivalve CYP proteins, and understand their roles in xenobiotic detoxification and physiology ...Continue Reading

References

Oct 1, 1989·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D R LivingstoneA Wiseman
Oct 6, 1999·Genome Research·X Huang, A Madan
May 5, 2004·Genome Research·Ewan BirneyRichard Durbin
Jun 14, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Kim F RewitzOle Andersen
Sep 5, 2006·Aquatic Toxicology·Bjørn Einar GrøsvikAnders Goksøyr
Feb 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dennis HedgecockBen Bowen
Jul 16, 2008·Marine Biotechnology·Steven RobertsFrederick Goetz
Feb 11, 2009·BMC Genomics·Paola VenierGerolamo Lanfranchi

❮ Previous
Next ❯

Citations

Oct 31, 2015·Annual Review of Animal Biosciences·Guofan ZhangLinlin Zhang
Mar 2, 2016·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Yuefeng CaiJingjing Miao
Mar 21, 2015·Environmental Science and Pollution Research International·Elsa BonnaféFlorence Geret
Nov 12, 2013·Toxicology and Industrial Health·Nahla Elsayed Omran, Wesam Mohamed Salama
May 6, 2014·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·A A ReunovA V Adrianov
Jun 25, 2015·Molecular Cytogenetics·Daniel García-SoutoJuan J Pasantes
Jun 7, 2011·Journal of Environmental Monitoring : JEM·Samantha Eslava Martins, Adalto Bianchini
Apr 15, 2015·Environmental Science and Pollution Research International·Fabrício Flores-NunesAfonso C D Bainy
Oct 18, 2019·International Journal of Biological Macromolecules·Sana SharifianSeema Patel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.