Identification of CYP2D6 null variants among long-stay, chronic psychiatric inpatients: is it strictly necessary?

Human Psychopharmacology
Ana Fernández-SantanderFélix Gómez-Gallego

Abstract

We identified the null variants *3,*4,*5,*6,*7 and *8 of the CYP2D6 gene [encoding for cytochrome P450 (debrisoquine hydroxylase)] in a group of 84 chronic-stay psychiatric inpatients with severe schizophrenia or related disorders and receiving treatment with one or more CYP2D6 substrates for years. We also studied a group of 100 healthy controls of similar ethnic origin (Spanish Caucasians). Three patients were poor metabolizers (PMs) for antipsychotic drugs according to their CYP2D6 genotype (i.e. homozygous for the *4 allele) but they exhibited no adverse drug reaction over the years despite chronic treatment with CYP2D6 substrates. We suggest that CYP2D6 genetic screening is more useful in other type of psychiatric patients, particularly in younger ones starting treatment protocols.

References

Apr 1, 1994·Clinical Pharmacology and Therapeutics·J A AgúndezJ Benítez
Feb 24, 2001·European Journal of Clinical Pharmacology·M G ScordoF Sjöqvist
Feb 20, 2002·British Journal of Clinical Pharmacology·Leif BertilssonAyman Al-Shurbaji
Oct 5, 2002·The Journal of Clinical Psychiatry·Robert M A HirschfeldMarcio Versiani
Jan 27, 2005·The Journal of Clinical Psychiatry·Jose de LeonPeter J Wedlund
Apr 30, 2005·Pharmacogenetics and Genomics·Nikolaos A PatsopoulosJohn P A Ioannidis
Jul 29, 2005·Psychiatry and Clinical Neurosciences·Daiji KatoYoshio Hirayasu
Sep 1, 2005·Cell Biochemistry and Function·Anna MenoyoMontserrat Baiget
Mar 16, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·J O RasmussenK A Nielsen

❮ Previous
Next ❯

Citations

Sep 19, 2009·Pharmacogenomics·Fabiana B KohlrauschMara H Hutz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

Expert Review of Pharmacoeconomics & Outcomes Research
Mark Oremus
The New England Journal of Medicine
Susan B Shurin, Elizabeth G Nabel
The New England Journal of Medicine
Victor J Navarro, John R Senior
Expert Review of Clinical Pharmacology
John A VernonJoseph H Golec
© 2022 Meta ULC. All rights reserved