Identification of cytotoxic T lymphocyte epitopes on swine viruses: multi-epitope design for universal T cell vaccine

PloS One
Yu-Chieh LiaoWen-Bin Chung

Abstract

Classical swine fever (CSF), foot-and-mouth disease (FMD) and porcine reproductive and respiratory syndrome (PRRS) are the primary diseases affecting the pig industry globally. Vaccine induced CD8(+) T cell-mediated immune response might be long-lived and cross-serotype and thus deserve further attention. Although large panels of synthetic overlapping peptides spanning the entire length of the polyproteins of a virus facilitate the detection of cytotoxic T lymphocyte (CTL) epitopes, it is an exceedingly costly and cumbersome approach. Alternatively, computational predictions have been proven to be of satisfactory accuracy and are easily performed. Such a method enables the systematic identification of genome-wide CTL epitopes by incorporating epitope prediction tools in analyzing large numbers of viral sequences. In this study, we have implemented an integrated bioinformatics pipeline for the identification of CTL epitopes of swine viruses including the CSF virus (CSFV), FMD virus (FMDV) and PRRS virus (PRRSV) and assembled these epitopes on a web resource to facilitate vaccine design. Identification of epitopes for cross protections to different subtypes of virus are also reported in this study and may be useful for the develo...Continue Reading

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Citations

Jun 21, 2016·Transboundary and Emerging Diseases·L RobinsonW Vosloo
Mar 26, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Neha SangewarWaithaka Mwangi
Aug 11, 2021·Pharmaceutics·Mohammad O FaruckIstvan Toth

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Datasets Mentioned

BETA
AF308157
AAG45408

Software Mentioned

MySQL
ICES
NetCTLpan
NetMHCpan
NetChop
Linux

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