Identification of degradation products from aqueous carboplatin injection samples by electrospray mass spectrometry

International Journal of Pharmaceutics
Kannan VivekanandanAnand C Burman

Abstract

Four different carboplatin injection samples in water ( approximately 10mg/ml) stored at room temperature were investigated for degradation products by electrospray liquid chromatography-mass spectrometry (ESI/LC-MS). A mass spectrometer compatible mobile phase system with 0.02% formic acid and methanol was used to resolve the impurities. Possible chemical structures of the unknown impurities and its degradation mechanism were proposed based on its experimental results and literature findings.

Citations

Nov 12, 2013·Annales pharmaceutiques françaises·J VigneronF Pinguet
Jan 3, 2007·Journal of Mass Spectrometry : JMS
Apr 5, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Anthony J Di PasquaJames C Dabrowiak
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Jun 4, 2011·Chemical Communications : Chem Comm·Adam D MartinColin L Raston
Nov 13, 2010·Metallomics : Integrated Biometal Science·Diego Esteban-FernándezMaría Milagros Gómez-Gómez
May 20, 2017·European Journal of Medicinal Chemistry·Sanjeewa N SenadheeraM Laird Forrest

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