Identification of Dengue and Chikungunya Cases Among Suspected Cases of Yellow Fever in the Democratic Republic of the Congo

Vector Borne and Zoonotic Diseases
Sheila Makiala-MandandaJ J Muyembe-Tamfum

Abstract

For more than 95% of acute febrile jaundice cases identified through surveillance for yellow fever, a reemerging arthropod-borne viral disease, no etiological exploration is ever done. The aim of this study was to test for other arthropod-borne viruses that can induce the same symptoms in patients enrolled in the yellow fever surveillance in the Democratic Republic of the Congo (DRC). Of 652 patients included in the surveillance of yellow fever in DRC from January 2003 to January 2012, 453 patients that tested negative for yellow fever virus (YFV) immunoglobulin M (IgM) antibodies were selected for the study. Real-time polymerase chain reaction was performed for the detection of dengue, West Nile, Chikungunya, O'nyong-nyong, Rift Valley fever, Zika, and YFV. The average age of patients was 22.1 years. We reported 16 cases (3.5%; confidence interval [CI]: 0.8-5.2) of dengue (serotypes 1 and 2) and 2 cases (0.4%; CI: 0.0-1.0) of Chikungunya. Three patients were co-infected with the two serotypes of dengue virus. Three cases of dengue were found in early July 2010 from the city of Titule (Oriental province) during a laboratory-confirmed outbreak of yellow fever, suggesting simultaneous circulation of dengue and yellow fever viruse...Continue Reading

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Citations

Feb 28, 2020·Parasites & Vectors·Kennedy M MbanzuluSharadhuli I Kimera
Sep 17, 2020·Viruses·Francesco Vairo On Behalf Of The Pandora-Id-Net Consortium Chikungunya Outbreak Group Taskforce
Jul 2, 2019·Japanese Journal of Infectious Diseases·Seiji P YamamotoNobuhiro Iritani
Apr 21, 2020·Pathogens and Global Health·Gianluca RussoGiovanni Rezza
Feb 2, 2021·Parasites & Vectors·Francis Wat'senga TezzoVeerle Vanlerberghe
Dec 24, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Francesca ColavitaConcetta Castilletti
Feb 6, 2021·The Journal of Infectious Diseases·Nilton Barnabé RodriguesNagila Francinete Costa Secundino
Aug 18, 2021·PLoS Neglected Tropical Diseases·Patrick Mukadi KakoniChris Smith
Aug 29, 2021·Pathogens·Rachel Milomba VeluEdgar Simulundu

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Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

7500 system SDS

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