Identification of didecyldimethylammonium salts and salicylic acid as antimicrobial compounds in commercial fermented radish kimchi

Journal of Agricultural and Food Chemistry
Jing LiJohn C Vederas

Abstract

Daikon radish (Raphanus sativus) fermented with lactic acid bacteria, especially Leuconostoc or Lactobacillus spp., can be used to make kimchi, a traditional Korean fermented vegetable. Commercial Leuconostoc/radish root ferment filtrates are claimed to have broad spectrum antimicrobial activity. Leuconostoc kimchii fermentation products are patented as preservatives for cosmetics, and certain strains of this organism are reported to produce antimicrobial peptides (bacteriocins). We examined the antimicrobial agents in commercial Leuconostoc/radish root ferment filtrates. Both activity-guided fractionation with Amberlite XAD-16 and direct extraction with ethyl acetate gave salicylic acid as the primary agent with activity against Gram-negative bacteria. Further analysis of the ethyl acetate extract revealed that a didecyldimethylammonium salt was responsible for the Gram-positive activity. The structures of these compounds were confirmed by a combination of (1)H- and (13)C NMR, high-performance liquid chromatography, high-resolution mass spectrometry, and tandem mass spectrometry analyses. Radiocarbon dating indicates that neither compound is a fermentation product. No antimicrobial peptides were detected.

References

Feb 1, 1996·Antonie van Leeuwenhoek·J Delves-BroughtonJ Hugenholtz
Jul 17, 2001·Journal of Agricultural and Food Chemistry·G TakeokaN Mahoney
Oct 18, 2002·International Journal of Food Microbiology·R Paul RossC Hill
Oct 6, 2005·Nature Reviews. Microbiology·Paul D CotterR Paul Ross
Oct 25, 2006·Antimicrobial Agents and Chemotherapy·Christopher J IoannouStephen P Denyer
Jul 10, 2007·Applied and Environmental Microbiology·Anders BrobergJohan Schnürer
Sep 11, 2007·Journal of Molecular Microbiology and Biotechnology·Luc De Vuyst, Frédéric Leroy
Nov 6, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kamil KucaDaniel Jun
Feb 12, 2009·Contact Dermatitis·Michael Dyrgaard LundovJeanne Duus Johansen
Apr 30, 2009·Annual Review of Phytopathology·A Corina VlotDaniel F Klessig
Sep 19, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Aya OhnumaTakanori Harada
Apr 13, 2011·Contact Dermatitis·Athamaica Ruiz OropezaJeanne Duus Johansen
Sep 1, 2011·Food & Function·Garry G Duthie, Adrian D Wood
Mar 6, 2012·Annual Review of Food Science and Technology·Vijay K JunejaXianghe Yan
Mar 17, 2012·International Journal of Antimicrobial Agents·Sylvie Buffet-BataillonAnne Jolivet-Gougeon
Mar 31, 2012·International Journal of Food Microbiology·Pradeep Singh Negi
Aug 23, 2012·Advances in Food and Nutrition Research·Agata M PawlowskaElke K Arendt
Nov 22, 2012·Journal of the American Chemical Society·Christopher T LohansJohn C Vederas
Mar 19, 2013·Meat Science·Liz KarreKelly J K Getty
Sep 12, 2013·The Journal of Antibiotics·Christopher T Lohans, John C Vederas
Jan 3, 2014·Chembiochem : a European Journal of Chemical Biology·Christopher T LohansJohn C Vederas
Jan 30, 2014·Journal of the American Academy of Dermatology·Raman K Madan, Jacob Levitt
Jul 9, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pu JingBing-Jun Qian

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