Identification of differential microRNAs in cerebrospinal fluid and serum of patients with major depressive disorder

PloS One
Yunqiang WanChunxiang Zhang

Abstract

Major depression is a debilitating disease. To date, the development of biomarkers of major depressive disorder (MDD) remains a challenge. Recently, alterations in the expression of microRNAs (miRNAs) from post-mortem brain tissue and peripheral blood have been linked to MDD. The goals of this study were to detect the differential miRNAs in cerebrospinal fluid (CSF) and serum of MDD patients. First, the relative expression levels of 179 miRNAs (relative high levels in serum) were analyzed by miRNA PCR Panel in the CSF of MDD patients. Then, the differentially altered miRNAs from CSF were further assessed by qRT-PCR in the serum of the same patients. Finally, the serum differentially altered miRNAs were further validated by qRT-PCR in the serum of another MDD patients. The CSF-results indicated that 11 miRNAs in MDD patients were significantly higher than these in control subjects, and 5 miRNAs were significantly lower than these in control subjects. The serum-results from the same patients showed that 3 miRNAs (miR-221-3p, miR-34a-5p, and let-7d-3p) of the 11 miRNAs were significantly higher than these in control subjects, and 1 miRNA (miR-451a) of 5 miRNAs was significantly lower than these in control subjects. The up-regulati...Continue Reading

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Citations

Feb 24, 2016·Frontiers in Genetics·Nicoleta StoiceaSergio D Bergese
Dec 3, 2015·Biochemical Pharmacology·Bisrat T Woldemichael, Isabelle M Mansuy
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Aug 3, 2018·Journal of Affective Disorders·Yogesh Dwivedi

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Methods Mentioned

BETA
PCR

Software Mentioned

SPSS
PicTar
miRNome
GenEx qPCR
Exiqon
GraphPad
GraphPad Prism
Target Scan
miRanda

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