Identification of Differential Tumor Subtypes of T1 Bladder Cancer.

European Urology
A Gordon RobertsonJoshua J Meeks

Abstract

Stage T1 bladder cancers have the highest progression and recurrence rates of all non-muscle-invasive bladder cancers (NMIBCs). Most T1 cancers are treated with bacillus Calmette-Guérin (BCG), but many will progress or recur, and some T1 patients will die from bladder cancer. Particularly aggressive tumors could be treated with early cystectomy. To better understand the molecular heterogeneity of T1 cancers, we performed transcriptome profiling and unsupervised clustering, and identified five consensus subtypes of T1 tumors treated with repeat transurethral resection (reTUR) and induction and maintenance BCG. The T1-LumGU subtype was associated with carcinoma in situ (CIS; six/13, 46% of all CIS), had high E2F1 and EZH2 expression, and was enriched in E2F target and G2M checkpoint hallmarks. The T1-Inflam subtype was inflamed and infiltrated with immune cells. While most T1 tumors were classified as luminal papillary, the T1-TLum subtype had the highest median luminal papillary score and FGFR3 expression, no recurrence events, and the fewest copy number gains. T1-Myc and T1-Early subtypes had the most recurrences (14/30 within 24 mo), the highest median MYC expression, and, when combined, had significantly worse recurrence-free...Continue Reading

References

Jun 21, 2016·Cancer Cell·Jakob HedegaardLars Dyrskjøt
Oct 18, 2016·Oncotarget·Joshua J MeeksFrancis J Giles
Sep 30, 2019·European Urology·Aurélie KamounUNKNOWN Bladder Cancer Molecular Taxonomy Group
Oct 2, 2019·Nature Biotechnology·Nike BeaubierKevin P White

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Citations

Apr 23, 2021·Human Pathology·Antonio Lopez-BeltranLiang Cheng
May 8, 2021·Hematology/oncology Clinics of North America·David J McConkey
Jun 13, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeffrey S DamrauerEugene J Pietzak
Oct 27, 2021·The Journal of Pathology. Clinical Research·Chelsea L JacksonDavid M Berman

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