Identification of differentially expressed genes in cervical cancer by bioinformatics analysis

Oncology Letters
Yanshan GeYanhong Zhou

Abstract

Cervical cancer is the most common gynecological malignancy. In recent years, the incidence of cervical cancer has had a younger trend. Cervical cancer morbidity and mortality rates have been significantly reduced due to recent decades of cervical cytology screening leading to the early detection and treatment of cervical cancer and precancerous lesions. There are a number of methods used to treat cervical cancer and improve the survival rate. However, the prevalence and recurrence rates of cervical cancer are increasing every year. There is an urgent requirement for a better understanding of the molecular mechanism cervical cancer development. The present study used scientific information retrieval from the Gene Expression Omnibus database to download the GSE26511 dataset, which contained 39 samples, including 19 cervical cancer lymph node-positive samples and 20 cervical cancer lymph node-negative samples. Using Gene Ontology analysis, Kyoto Encyclopedia of Genes and Genomes analysis, and weighted gene co-expression network analysis, 1,263 differentially expressed genes were found that affected the biological processes, including 'cell cycle process', 'signaling pathways', 'immune response', 'cell activation', 'regulation of ...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Dec 31, 2008·BMC Bioinformatics·Peter Langfelder, Steve Horvath
Feb 23, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Qing YeLei Huang
Mar 10, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maartje G NoordhuisEd Schuuring
Apr 27, 2013·Lancet·Emma J CrosbieHenry C Kitchener
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Oct 8, 2015·The Journal of Biological Chemistry·Weisi LiuJianxin Gu
Jun 15, 2016·The Lancet Oncology·Enrica BentivegnaPhilippe Morice
Jul 3, 2016·Neuro-oncology·Nicolas GoffartBernard Rogister
Oct 30, 2016·European Journal of Immunology·Xiao WangHong Sjölinder
Apr 1, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Paul J CollinsBernhard Moser
Apr 11, 2017·Gynecologic Oncology·Glauco BaiocchiLillian Yuri Kumagai
May 11, 2017·Biochemical and Biophysical Research Communications·Shuang ChangYongting Wang
Jun 10, 2017·Expert Review of Anticancer Therapy·Parnaz MerikhianKeivan Majidzadeh-A
Jun 16, 2017·Cancer Cell International·Ai-Hua ChenManzhen Zuo
Jul 6, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Eun Young KimYoon Soo Chang
Sep 21, 2017·Mutation Research. Reviews in Mutation Research·Maria de Fátima Senra CardosoJosé António Couto Teixeira
Sep 22, 2017·Cell Cycle·Shenglong QiuTao Liu
Oct 12, 2017·Gene·Wenfang MengYe Chen
Jan 23, 2018·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Tong ShuLingying Wu
Mar 24, 2018·The Oncologist·Ulrike MoelleEva J Kantelhardt
Mar 28, 2018·Journal of Cancer·Jian-Guo ChenGao-Ren Wang
Apr 15, 2018·Clinical Oncology : a Journal of the Royal College of Radiologists·C ShelleyR Eeles
Apr 21, 2018·Journal of Cancer·Min YangAiguo Tang
Apr 24, 2018·Gynecologic Oncology Reports·Rose Isono-NakataHiroaki Shibahara

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.