Identification of discrete, intermingled hypocretin neuronal populations

The Journal of Comparative Neurology
Manasi IyerMatthew E Carter

Abstract

Neurons in the lateral hypothalamic area that express hypocretin (Hcrt) neuropeptides help regulate many behaviors including wakefulness and reward seeking. These neurons project throughout the brain, including to neural populations that regulate wakefulness, such as the locus coeruleus (LC) and tuberomammilary nucleus (TMN), as well as to populations that regulate reward, such as the nucleus accumbens (NAc) and ventral tegmental area (VTA). To address the roles of Hcrt neurons in seemingly disparate behaviors, it has been proposed that Hcrt neurons can be anatomically subdivided into at least two distinct subpopulations: a "medial group" that projects to the LC and TMN, and a "lateral group" that projects to the NAc and VTA. Here, we use a dual retrograde tracer strategy to test the hypotheses that Hcrt neurons can be classified based on their downstream projections and medial/lateral location within the hypothalamus. We found that individual Hcrt neurons were significantly more likely to project to both the LC and TMN or to both the VTA and NAc than would be predicted by chance. In contrast, we found that Hcrt neurons that projected to the LC or TMN were mostly distinct from Hcrt neurons that projected to the VTA or NAc. Inte...Continue Reading

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Citations

Jan 11, 2020·Sleep·A R AdamantidisThomas E Scammell
Mar 7, 2020·Neuropharmacology·Shi-Bin Li, Luis de Lecea
Mar 3, 2020·Brain Research·Anushree N Karkhanis, Ream Al-Hasani
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Aug 21, 2021·Peptides·Daria Peleg-Raibstein, Denis Burdakov
Sep 7, 2021·Physiological Reviews·Alan G WattsWolfgang Langhans

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