Identification of DXCF cyanobacteriochrome lineages with predictable photocycles

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
Nathan C RockwellJ Clark Lagarias

Abstract

Diverse organisms use phytochrome photoreceptors to measure the ratio of red to far-red light in their respective environments. In addition to red/far-red phytochromes, many cyanobacteria contain distantly related cyanobacteriochrome (CBCR) photosensors that also use photoisomerization of a covalently bound linear tetrapyrrole (bilin) chromophore to measure multiple colors of light. CBCRs exhibit a remarkable variety of photocycles spanning the near ultraviolet and the entire visible spectrum. One group of CBCRs, distinguished by the presence of a conserved Asp-Xaa-Cys-Phe (DXCF) motif or variations thereon, includes members with violet/green, blue/teal, blue/green, blue/yellow, blue/orange, green/blue and green/teal photocycles. To date, it has not proven possible to predict such photocycles from primary amino acid sequence. We here use site-directed mutagenesis, phylogenetic analysis, and characterization of six new CBCRs to probe structure/function relationships in DXCF CBCRs. This approach has defined two groups of DXCF CBCRs with specialized green/blue and blue/orange photocycles that are robustly predictable from primary sequence data. Such knowledge facilitates the use of CBCRs for synthetic photobiological applications ...Continue Reading

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Citations

Aug 5, 2015·Current Opinion in Structural Biology·Katrin Anders, Lars-Oliver Essen
Jun 14, 2016·Biochemistry·Nathan C RockwellJ Clark Lagarias
Jan 6, 2017·Photochemistry and Photobiology·Nathan C RockwellJohn Clark Lagarias
May 18, 2017·Physical Chemistry Chemical Physics : PCCP·Laura Katharina Scarbath-EversDaniel Sebastiani
Jan 21, 2017·The New Phytologist·Nathan C RockwellJohn Clark Lagarias
Aug 5, 2017·International Journal of Molecular Sciences·Olena S OliinykVladislav V Verkhusha
Oct 9, 2019·The New Phytologist·Nathan C Rockwell, J Clark Lagarias
Aug 14, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Keiji FushimiRei Narikawa
Oct 28, 2019·The Journal of Biological Chemistry·Teppei SatoYuu Hirose
Aug 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Dihao WangDongping Zhong
Mar 25, 2017·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Yuu HiroseToshihiko Eki
Jun 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·Keiji FushimiRei Narikawa
Oct 28, 2020·Proceedings of the National Academy of Sciences of the United States of America·Marcus V MorenoJ Clark Lagarias
Apr 10, 2017·Current Opinion in Plant Biology·Ming-Yang HoDonald A Bryant
Mar 18, 2021·Proceedings of the National Academy of Sciences of the United States of America·Sepalika BandaraXiaojing Yang
Dec 10, 2016·Biochemistry·Keiji FushimiRei Narikawa
Sep 18, 2020·The Journal of Physical Chemistry Letters·Dihao WangDongping Zhong
Aug 14, 2020·Biochemistry·Samantha J O HardmanNigel S Scrutton

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