Identification of early HIV infections using the fourth generation Abbott ARCHITECT HIV Ag/Ab Combo chemiluminescent microparticle immunoassay (CIA) in San Diego County

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Anna Liza M ManlutacPatricia A McVay

Abstract

HIV screening assays have gone through several generations of development in an effort to narrow the "window period" of detection. Utilizing a fourth generation HIV screening assay has the potential to detect earlier HIV infection, thus reducing HIV-1 transmission. To identify acute infections to decrease HIV transmission in San Diego County. Serum specimens were collected from clients seen by multiple submitters in San Diego County. All acceptable specimens were screened using the 4th Gen Combo Assay. Initially reactive specimens were repeated in duplicate and if repeatedly reactive, were confirmed by HIV-1 Immunofluorescent Antibody Assay (IFA). IFA negative/inconclusive specimens were sent for HIV-1 NAT and HIV-2 antibody testing to referral laboratories. BioRad Multispot HIV-1/HIV-2 Rapid Test was also performed on a subset of specimens. Of 14,559 specimens received in 20 months, 14,517 specimens were tested. Of the 14,517 specimens that were tested, a total of 279 (1.9%) specimens were CIA repeatedly reactive and 240 of the 279 confirmed by HIV-1 IFA. Thirty-nine gave IFA negative/inconclusive result and 30 were further tested for HIV-1 NAT and 36 for HIV-2 antibody. Thirteen specimens were considered false positives by CI...Continue Reading

References

Oct 26, 2006·Medical Care·Bruce R SchackmanKenneth A Freedberg
Oct 12, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ana María CárdenasRichard L Hodinka

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Citations

Aug 17, 2014·Annals of Emergency Medicine·Jason S HaukoosRichard E Rothman
May 14, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sanjay R MehtaDavey M Smith
Jun 23, 2016·Cell and Tissue Banking·Thayssa Neiva da Fonseca VicterThatiane Lima Sampaio
Oct 11, 2014·Expert Review of Molecular Diagnostics·Daniel A McPartlin, Richard J O'Kennedy
Oct 12, 2016·Microbiology Spectrum·Wendy S ArmstrongAngela M Caliendo
Aug 2, 2021·The Journal of Applied Laboratory Medicine·Matthew D KrasowskiSihe Wang

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