PMID: 11328453May 1, 2001Paper

Identification of efferent neural pathways from the lamina terminalis activated by blood-borne relaxin

Journal of Neuroendocrinology
N SunnB J Oldfield

Abstract

The ovarian hormone relaxin, in addition to its role in pregnancy, exerts an action on the brain to influence oxytocin and vasopressin secretion, water drinking, and cardiovascular function. Intravenous (i.v.) infusion of relaxin causes an acute water drinking response, confirming its role as a dipsogenic hormone. The aim of this study was to determine whether neurones in the lamina terminalis, which project to the hypothalamic paraventricular and supraoptic nuclei, are activated by elevated levels of circulating relaxin in conscious rats. Immunocytochemistry combined with retrograde neuronal tracing with cholera toxin B subunit conjugated to cholera toxin B (CTB-gold) was used to identify populations of neurones responding with elevated cells of Fos protein to i.v. relaxin administration and which project to these specific hypothalamic sites. Neurones exhibiting Fos were present in the outer parts of the subfornical organ (SFO), the dorsal part of the organum vasculosum (OVLT), the supraoptic nucleus and the paraventricular nucleus. These did not occur in control rats with i.v. infusions of isotonic saline. Approximately 90% of neurones concentrated in the outer parts of the SFO and in the dorsal OVLT showed both retrogradely ...Continue Reading

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Citations

Sep 11, 2010·Acta Neuropathologica·Sílvia SisóLorenzo González
Dec 23, 2003·Regulatory Peptides·G Trevor Cottrell, Alastair V Ferguson
Mar 1, 2003·Frontiers in Neuroendocrinology·John A RussellAlison J Douglas
Dec 21, 2002·Acta Physiologica Scandinavica·G M ToneyS D Stocker
Jul 10, 2012·Journal of Applied Physiology·Alexander Gabor, Frans H H Leenen
Feb 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·N SunnM J McKinley
Mar 10, 2010·Cellular and Molecular Life Sciences : CMLS·G E Callander, R A D Bathgate
May 2, 2006·Pharmacology & Therapeutics·Thomas DschietzigKarl Stangl
May 15, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Suwit J SomponpunCelia D Sladek
Oct 3, 2003·Biology of Reproduction·Maria Caterina BaccariDaniele Bani
Apr 15, 2004·Endocrine Reviews·O David Sherwood
May 29, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Masha Prager-Khoutorsky, Charles W Bourque
Jan 11, 2013·Physiological Reviews·R A D BathgateR J Summers
Sep 25, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K Max ColdrenCheryl M Heesch

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