Identification of factors associated with treatment refractoriness of oral lesions in pemphigus vulgaris

The British Journal of Dermatology
S KumarS Sarkar

Abstract

The oral mucosal lesions of patients with pemphigus vulgaris are known to show more treatment refractoriness than skin lesions. To identify which clinical and laboratory parameters may indicate treatment refractoriness of oral lesions in pemphigus vulgaris. This was a prospective study of 50 adults with pemphigus vulgaris and oral lesions; patients were given treatment appropriate for overall disease severity. Treatment refractoriness was defined arbitrarily as less than 75% reduction in oral objective Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) after treatment for 6 months. Of 46 patients who completed the study, 17 (37%) were treatment refractory whereas 29 (63%) were treatment responsive. At baseline, the treatment refractory group had a significantly longer mean duration of disease (P = 0·02) and mean duration of oral lesions (P = 0·01), a higher percentage of lesions in the retromolar trigone (P = 0·05) and on the occlusion line along the buccal mucosa (P = 0·04), a higher percentage of deep/crateriform ulcers (P < 0·001) and erosions with a lichenoid hue (P < 0·001). Herpes simplex virus (HSV) DNA positivity, assessed by polymerase chain reaction in oral tissue scrapings (P = 0·02), was also significantly hig...Continue Reading

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Citations

Jan 10, 2018·The British Journal of Dermatology·H Yuan, M Pan
Mar 13, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Paolo G ArduinoMarco Carrozzo
Dec 17, 2019·International Journal of Dermatology·Pierre-Antoine DouardChristophe Bédane
Sep 29, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Orsolya N HorváthMiklós Sárdy
Sep 10, 2019·Lancet·Enno SchmidtPascal Joly
Jul 11, 2021·Indian Journal of Dermatology, Venereology and Leprology·Anuradha BishnoiRahul Mahajan
Nov 26, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Dipankar DeShubh Mohan Singh

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