Identification of Felis catus Gammaherpesvirus 1 in Tsushima Leopard Cats (Prionailurus bengalensis euptilurus ) on Tsushima Island, Japan

Viruses
Isaac MakundiKazuo Nishigaki

Abstract

Felis catus gammaherpesvirus 1 (FcaGHV1) is a widely endemic infection of domestic cats. Current epidemiological data identify domestic cats as the sole natural host for FcaGHV1. The Tsushima leopard cat (TLC; Prionailurus bengalensis euptilurus) is a critically endangered species that lives only on Tsushima Island, Nagasaki, Japan. Nested PCR was used to test the blood or spleen of 89 TLCs for FcaGHV1 DNA; three (3.37%; 95% CI, 0.70⁻9.54) were positive. For TLC management purposes, we also screened domestic cats and the virus was detected in 13.02% (95% CI, 8.83⁻18.27) of 215 cats. Regarding phylogeny, the partial sequences of FcaGHV1 from domestic cats and TLCs formed one cluster, indicating that similar strains circulate in both populations. In domestic cats, we found no significant difference in FcaGHV1 detection in feline immunodeficiency virus-infected (p = 0.080) or feline leukemia virus-infected (p = 0.163) cats, but males were significantly more likely to be FcaGHV1 positive (odds ratio, 5.86; 95% CI, 2.27⁻15.14) than females. The higher frequency of FcaGHV1 detection in domestic cats than TLCs, and the location of the viral DNA sequences from both cats within the same genetic cluster suggests that virus transmission f...Continue Reading

References

Mar 29, 2001·Journal of Wildlife Diseases·J M SleemanS V Woude
Dec 8, 2005·Veterinary Microbiology·Mathias Ackermann
Jul 20, 2010·Cell Host & Microbe·Samuel H Speck, Don Ganem
Jan 12, 2011·Annual Review of Immunology·Erik BartonSamuel H Speck
Mar 2, 2013·The Journal of Veterinary Medical Science·Morihiro TatenoYasuyuki Endo
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Aug 20, 2016·Virology·Kathryn Stutzman-RodriguezRyan M Troyer
Aug 8, 2017·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Isaac MakundiKazuo Nishigaki
Sep 1, 2017·The Journal of Veterinary Medical Science·Morihiro TatenoYasuyuki Endo

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Datasets Mentioned

BETA
KF840715
KT595939

Methods Mentioned

BETA
PCR
electrophoresis
PCRs
ELISAs
amplicon sequencing

Software Mentioned

MEGA6
GeneTyx Blast
Minitab Statistical
BioEdit
Minitab
ClustalW

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