Identification of four Aconitum species used as "Caowu" in herbal markets by 3D reconstruction and microstructural comparison

Microscopy Research and Technique
Chan-Chan LiuLuqi Huang

Abstract

Authentication is the first priority when evaluating the quality of Chinese herbal medicines, particularly highly toxic medicines. The most commonly used authentication methods are morphological identification and microscopic identification. Unfortunately, these methods could not effectively evaluate some herbs with complex interior structures, such as root of Aconitum species with a circular conical shape and an interior structure with successive changes. Defining the part that should be selected as the standard plays an essential role in accurate microscopic identification. In this study, we first present a visual 3D model of Aconitum carmichaeli Debx. constructed obtained from microscopic analysis of serial sections. Based on this model, we concluded that the point of largest root diameter should be used as the standard for comparison and identification. The interior structure at this point is reproducible and its shape and appearance can easily be used to distinguish among species. We also report details of the interior structures of parts not shown in the 3D model, such as stone cells and cortical thickness. To demonstrate the usefulness of the results from the 3D model, we have distinguished the microscopic structures, at...Continue Reading

References

Nov 1, 1981·Journal of Ethnopharmacology·N G Bisset
Sep 12, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Thomas Y K Chan
Nov 19, 2004·Fundamental & Clinical Pharmacology·Angélica M Bello-Ramírez, Alejandro A Nava-Ocampo
Aug 5, 2009·Journal of Ethnopharmacology·Judith SinghuberBrigitte Kopp
Mar 17, 2010·Microscopy Research and Technique·Ignacio Arganda-CarrerasCarlos Ortiz-De-Solorzano
Mar 16, 2012·Microscopy Research and Technique·Bo Heum KimSang Joon Lee
Sep 25, 2012·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·Jun WangHuasheng Peng

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