Abstract
Maintaining skeletal muscle functions by controlling muscle metabolism is of utmost importance. β2-Adrenergic receptor (β2-AR), which is expressed in skeletal muscle, is a member of the G-protein-coupled receptor family that plays a critical role in the maintenance of muscle mass. In the present study, using luciferase reporter assays in β2-AR-expressing HEK293 cells, we discovered several food factors that exhibited agonistic activity at mouse or human β2-AR. Osthole, gramine, and hordenine were identified as both mouse and human β2-AR agonists, whereas berberine was identified as a mouse β2-AR agonist only. Additionally, intramuscular injection of gramine or hordenine in mice facilitated gene expression of several cAMP response element binding protein targets, which is thought to result in increased skeletal muscle protein synthesis. This study provides evidence that several food factors might exert potential health effects on skeletal muscle by enhancing cAMP signaling through the activation of β2-AR.
References
Aug 24, 1999·The Journal of Biological Chemistry·R SatoM Maeda
Aug 26, 2000·British Journal of Pharmacology·H E HopkinsonS J Hill
Dec 6, 2001·European Journal of Pharmacology·S IwataY Ohizumi
Apr 28, 2004·Experimental Physiology·Maria Antonietta PellegrinoCarlo Reggiani
Mar 19, 2005·Journal of Applied Physiology·Tossaporn YimlamaiSooyeon Park
Jul 27, 2005·Peptides·Gaël Jean-BaptisteMichael T Greenwood
Oct 28, 2006·Journal of Applied Physiology·William O KlineSue C Bodine
May 1, 2007·Nature Medicine·Rebecca BerdeauxMarc Montminy
Oct 31, 2007·Journal of Agricultural and Food Chemistry·Bryant C NelsonLane C Sander
Apr 9, 2008·Physiological Reviews·Gordon S Lynch, James G Ryall
Apr 16, 2010·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN European Working Group on Sarcopenia in Older People
Oct 12, 2010·The Journal of Physiological Sciences : JPS·Emi KawasakiKentaro Kawanaka
Jun 23, 2011·Biochemical and Biophysical Research Communications·Eri OnoRyuichiro Sato
Sep 29, 2011·American Journal of Physiology. Endocrinology and Metabolism·Dawit A P GonçalvesLuiz C C Navegantes
Oct 27, 2011·PloS One·Weizhi ZhangYi-Tang Tseng
Nov 22, 2011·Journal of Agricultural and Food Chemistry·Wei-Hwa LeeYu-Chih Liang
Feb 23, 2012·American Journal of Physiology. Endocrinology and Metabolism·Rebecca Berdeaux, Randi Stewart
Dec 12, 2012·Cell·Jorge L RuasBruce M Spiegelman
Nov 19, 2013·Critical Reviews in Biochemistry and Molecular Biology·Marc A Egerman, David J Glass
Mar 29, 2014·The EMBO Journal·Nelson E BrunoMichael D Conkright
Jul 1, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yanhong WeiShaoyong Ke
Jan 22, 2015·Molecular and Cellular Biology·Peter TontonozLily C Chao
Jun 9, 2015·PloS One·Daisuke UmekiSatoshi Okumura
Sep 5, 2015·The Journal of Biological Chemistry·Scott M EbertChristopher M Adams
May 28, 2016·The Journal of Biological Chemistry·Vicente Martínez-RedondoJorge L Ruas
Jun 10, 2016·Journal of Medicinal Chemistry·Rocío Lajarín-CuestaCristóbal de Los Ríos