Identification of functional progenitor cells in the pulmonary vasculature.

Pulmonary Circulation
Amy L Firth, Jason X-J Yuan

Abstract

The pulmonary vasculature comprises a complex network of branching arteries and veins all functioning to reoxygenate the blood for circulation around the body. The cell types of the pulmonary artery are able to respond to changes in oxygen tension in order to match ventilation to perfusion. Stem and progenitor cells in the pulmonary vasculature are also involved, be it in angiogenesis, endothelial dysfunction or formation of vascular lesions. Stem and progenitor cells may be circulating around the body, residing in the pulmonary artery wall or stimulated for release from a central niche like the bone marrow and home to the pulmonary vasculature along a chemotactic gradient. There may currently be some controversy over the pathogenic versus therapeutic roles of stem and progenitor cells and, indeed, it is likely both chains of evidence are correct due to the specific influence of the immediate environmental niche a progenitor cell may be in. Due to their great plasticity and a lack of specific markers for stem and progenitor cells, they can be difficult to precisely identify. This review discusses the methodological approaches used to validate the presence of and subtype of progenitors cells in the pulmonary vasculature while pu...Continue Reading

References

Jan 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J A Madri, B M Pratt
Nov 6, 1998·Science·J A ThomsonJ M Jones
Jun 18, 1999·Annals of the New York Academy of Sciences·S RobertsonG Keller
Jun 22, 2002·Nature·Yuehua JiangCatherine M Verfaillie
Nov 9, 2002·Experimental Hematology·Atsushi Asakura, Michael A Rudnicki
May 4, 2005·Current Opinion in Hematology·Elaine Dzierzak
Feb 25, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Chang-Hwan YoonHyo-Soo Kim
Sep 23, 2006·The New England Journal of Medicine·Steven E Artandi
May 15, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Frank TimmermansBart Vandekerckhove
Sep 21, 2007·American Journal of Respiratory and Critical Care Medicine·Gian Paolo FadiniCarlo Agostini
Dec 11, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Diego F AlvarezTroy Stevens
Dec 18, 2007·Experimental Cell Research·Nana MukaiIkuo Morita
Jan 18, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhaodi Gong, Laura E Niklason
Jan 31, 2008·Biochemical and Biophysical Research Communications·Ayuko HoshinoAtsushi Ochiai
Feb 22, 2008·Methods in Molecular Medicine·Keith R BruntLuis G Melo
Mar 20, 2008·Cardiovascular Research·Anna ZampetakiQingbo Xu
Aug 8, 2008·Proceedings of the American Thoracic Society·Michael R LoebingerSam M Janes
Nov 8, 2008·Journal of Applied Physiology·Syotaro ObiJoji Ando
Nov 22, 2008·Cold Spring Harbor Symposia on Quantitative Biology·M P ChaoI L Weissman
May 14, 2009·Transplantation·Valeria Sordi
May 14, 2009·Cancer Research·Michael R LoebingerSam M Janes
May 29, 2009·Veterinary Clinical Pathology·Tamara B WillsGary J Haldorson
Jul 9, 2009·Journal of the American College of Cardiology·Nicholas W MorrellE Kenneth Weir
Jul 8, 2009·Journal of Leukocyte Biology·Robert M StrieterBorna Mehrad
Jul 25, 2009·American Journal of Respiratory and Critical Care Medicine·Mark ToshnerNicholas W Morrell
Sep 29, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Soban UmarArnoud van der Laarse
Oct 20, 2009·Basic Research in Cardiology·Kiyoko TakemiyaTsutomu Imaizumi

❮ Previous
Next ❯

Citations

Aug 16, 2016·The American Journal of Pathology·Felicia Chen, Alan Fine
Jan 21, 2017·Journal of Tissue Engineering and Regenerative Medicine·E KardiaB H Yahaya
Dec 25, 2015·The European Respiratory Journal·Farhan SaboorRalf Middendorff

❮ Previous
Next ❯

Methods Mentioned

BETA
density gradient centrifugation
FACS
PCR
flow cytometry
chip
flow activated cell sorting
light
Assay

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.