Identification of galectins as novel regulators of platelet signaling and function

IUBMB Life
Maria Albertina RomaniukMirta Schattner

Abstract

Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug. Activation of platelets is therefore crucial for normal hemostasis. However, uncontrolled platelet activation may also lead to the formation of occlusive thrombi that can cause ischemic events. Platelets can be activated by soluble molecules including thrombin, TXA2 , adenosine diphosphate (ADP), and serotonin or by adhesive extracellular matrix (ECM) proteins such as von Willebrand factor and collagen. In this article, we review recent advances on the role of galectins in platelet physiology. By acting in either soluble or immobilized form, these glycan-binding proteins trigger platelet activation through modulation of discrete signaling pathways. We also offer new hypotheses and some speculations about the role of platelet-galectin interactions not only in hemostasis and thrombosis but also in inflammation and related diseases such as atherosclerosis and cancer.

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Citations

Jun 6, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Ming ZhongMuredach P Reilly
Mar 20, 2013·Biological Chemistry·Mirta Schattner, Gabriel A Rabinovich
Mar 16, 2017·Journal of Clinical Laboratory Analysis·Duygu KocyigitKudret Aytemir
Apr 10, 2017·Immunologic Research·Luiza Oliveira PerucciLirlândia Pires Sousa
Sep 22, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hannah BarrowLu-Gang Yu

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