PMID: 15218044Jun 26, 2004Paper

Identification of genes differentially regulated in rat alveolar bone wound healing by subtractive hybridization

Journal of Dental Research
T OhiraS Takashiba

Abstract

Periodontal healing requires the participation of regulatory molecules, cells, and scaffold or matrix. Here, we hypothesized that a certain set of genes is expressed in alveolar bone wound healing. Reciprocal subtraction gave 400 clones from the injured alveolar bone of Wistar rats. Identification of 34 genes and analysis of their expression in injured tissue revealed several clusters of unique gene regulation patterns, including the up-regulation at 1 wk of cytochrome c oxidase regulating electron transfer and energy metabolism, presumably occurring at the site of inflammation; up-regulation at 2.5 wks of pro-alpha-2 type I collagen involving the formation of a connective tissue structure; and up-regulation at 1 and 2 wks and down-regulation at 2.5 and 4 wks of ubiquitin carboxyl-terminal hydrolase l3 involving cell cycle, DNA repair, and stress response. The differential expression of genes may be associated with the processes of inflammation, wound contraction, and formation of a connective tissue structure.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jan 1, 1991·Annual Review of Cell Biology·D Finley, V Chau
Jan 26, 2002·Journal of Dental Research·S TakayamaH Okada
Jul 5, 2002·Journal of Dental Research·C QinW T Butler
May 20, 2003·Journal of Periodontal Research·Fumio MyokaiYoji Murayama

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Citations

Aug 20, 2005·Journal of Dental Research·M OyamaS Takashiba

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