Identification of genes involved in the host response to enterovirus 71 infection

Journal of Neurovirology
Shin-Ru ShihMei-Ling Li

Abstract

Enterovirus 71 (EV71) infection may be asymptomatic or may cause diarrhea, rashes, and hand, foot, and mouth disease (HFMD). However, EV71 also has the potential to cause severe neurological disease. To date, little is known about the molecular mechanisms of host response to EV71 infection. In this report, we utilized cDNA microarray to profile the kinetics and patterns of host gene expression in EV71-infected human neural SF268 cells. We have identified 157 genes with significant changes in mRNA expression and performed hierarchical clustering to classify these genes into five different groups based on their kinetics of expression. EV71 infection led to increases in the level of mRNAs encoding chemokines, proteins involved in protein degradation, complement proteins, and proapoptotis proteins. cDNA microarray expression comparisons of EV71- and mock-infected cells also revealed the down-regulation of several genes encoding proteins involved in host RNA synthesis. Expression of interferon-regulated proteins was increased early in the infection and then decreased. Expression of proteins involved in cellular development and differentiation, some oncogenes, and transcription and translation regulators were suppressed and then stim...Continue Reading

Citations

May 4, 2011·The Journal of Infectious Diseases·Hui-Chen HungJohn T-A Hsu
Jul 1, 2011·Journal of Virology·Shin-Ru ShihMei-Ling Li
Nov 1, 2011·World Journal of Gastroenterology : WJG·Jing LuMing-Liang He
Feb 25, 2014·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Hamid Reza Pourianfar, Lara Grollo
Mar 30, 2010·Microbes and Infection·Kuo-Feng WengShin-Ru Shih
Dec 12, 2012·Biochemical and Biophysical Research Communications·Zhixin YinChangwen Ke
May 5, 2017·Journal of Virology·Vidyanath ChaudharyDong-Yan Jin
Sep 28, 2020·Journal of Ethnopharmacology·Naixin KangShilin Yang
Jun 4, 2021·Communications Biology·Ya-Ling ChangSung-Liang Yu

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