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Identification of genetic variants in the human indoleamine 2,3-dioxygenase (IDO1) gene, which have altered enzyme activity

Pharmacogenetics and Genomics

Jun 11, 2009

Million ArefayeneTodd C Skaar

Abstract

Indoleamine 2,3-dioxygenase (IDO), a rate-limiting enzyme in tryptophan catabolism, is a key regulator of immune tolerance. We identified genetic variations in the IDO1 gene and evaluated their functional activities using in-vitro transfection studies. We resequenced the exons and the i...read more

Mentioned in this Paper

Tryptophan Catabolic Process
Transfection
HEK293 Cells
Immune System Diseases
Exons
COS-7 Cells
Gene Deletion Abnormality
Indoleamine-Pyrrole 2,3,-Dioxygenase
IDO1 gene
Enzyme Activity
1
17
Paper Details
References
  • References27
  • Citations16
123
  • References27
  • Citations16
12

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Immune Tolerance

Immune tolerance happens when the immune system is not responsive to a substance or organism and does not elicit an immune response. This is a normal physiological response for some antigens, especially when detecting self from non-self. This has been a potential area of therapy for some disorders. Here is the latest research on immune tolerance.

Chromosomal Deletion

Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.

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Identification of genetic variants in the human indoleamine 2,3-dioxygenase (IDO1) gene, which have altered enzyme activity

Pharmacogenetics and Genomics

Jun 11, 2009

Million ArefayeneTodd C Skaar

PMID: 19514129

DOI: 10.1097/fpc.0b013e32832c005a

Abstract

Indoleamine 2,3-dioxygenase (IDO), a rate-limiting enzyme in tryptophan catabolism, is a key regulator of immune tolerance. We identified genetic variations in the IDO1 gene and evaluated their functional activities using in-vitro transfection studies. We resequenced the exons and the i...read more

Mentioned in this Paper

Tryptophan Catabolic Process
Transfection
HEK293 Cells
Immune System Diseases
Exons
COS-7 Cells
Gene Deletion Abnormality
Indoleamine-Pyrrole 2,3,-Dioxygenase
IDO1 gene
Enzyme Activity
1
17

Similar Papers Found In These Feeds

Immune Tolerance

Immune tolerance happens when the immune system is not responsive to a substance or organism and does not elicit an immune response. This is a normal physiological response for some antigens, especially when detecting self from non-self. This has been a potential area of therapy for some disorders. Here is the latest research on immune tolerance.

Chromosomal Deletion

Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.

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Paper Details
References
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