Identification of geographic clustering and regions spared by cutaneous T-cell lymphoma in Texas using 2 distinct cancer registries

Cancer
Ivan V LitvinovMadeleine Duvic

Abstract

Cutaneous T-cell lymphomas (CTCLs) (mycosis fungoides and its leukemic variant, Sezary syndrome) are rare malignancies. Reports of the occurrence of mycosis fungoides in married couples and families raise the possibility of an environmental trigger for this cancer. Although it has been suggested that CTCL arises from inappropriate T-cell stimulation, to the authors' knowledge no preventable trigger has been identified to date. Using region, zip code, age, sex, and ethnicity, the authors analyzed the demographic data of 1047 patients from Texas who were seen in a CTCL clinic at The University of Texas MD Anderson Cancer Center during 2000 through 2012 (the MDACC database) and 1990 patients who were recorded in the population-based Texas Cancer Registry between 1996 and 2010. Subsequently, data from both databases were cross-analyzed and compared. The current study findings, based on the MDACC database, documented geographic clustering of patients in 3 communities within the Houston metropolitan area, in which CTCL incidence rates were 5 to 20 times higher than the expected population rate. Analysis of the Texas Cancer Registry database defined the CTCL population rate for the state to be 5.8 cases per million individuals per yea...Continue Reading

References

Jan 1, 1977·Dermatologica·P G Hazen, B Michel
Feb 1, 1991·The British Journal of Dermatology·M DetmarC E Orfanos
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M S ReitzR C Gallo
Mar 1, 1996·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·R A Buzzell
Sep 1, 1996·The Journal of Investigative Dermatology·C M JackowM Duvic
Mar 20, 2002·The British Journal of Dermatology·E HodakK Klein
Apr 20, 2004·Journal of Occupational and Environmental Medicine·Maria M Morales-Suárez-VarelaGiovanna Masala
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Mar 12, 2005·Journal of the American Academy of Dermatology·Emmilia HodakMichael David
Jul 20, 2007·Archives of Dermatology·Vincent D Criscione, Martin A Weinstock
Jul 21, 2007·Current Problems in Dermatology·Yonit Wohl, Ethel Tur
Nov 26, 2008·Journal of the American Academy of Dermatology·Grace SunMadeleine Duvic
Mar 18, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ivan V LitvinovThomas S Kupper
Aug 10, 2010·Journal of the American Academy of Dermatology·Ezra D MirvishLarisa J Geskin
Apr 20, 2012·The Journal of Investigative Dermatology·Marloes S van KesterCornelis P Tensen
Aug 2, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rakhshandra TalpurMadeleine Duvic
Oct 9, 2012·Clinical Lymphoma, Myeloma & Leukemia·Lynn D WilsonJames B Yu
Nov 10, 2013·Critical Care Medicine·Elizabeth K StevensonAllan J Walkey
Jan 1, 2010·Cancers·Gabriella FabbrociniGiuseppe Monfrecola
Jan 21, 2014·Journal of the American Academy of Dermatology·Sarah I JawedChristiane Querfeld
May 9, 2014·The International Journal of Biochemistry & Cell Biology·Piotr Czapiewski, Wojciech Biernat

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Citations

Mar 1, 2016·American Journal of Clinical Dermatology·Sumana Devata, Ryan A Wilcox
Oct 9, 2016·Seminars in Immunopathology·Thorbjørn KrejsgaardNiels Odum
Jul 22, 2017·Blood Cancer Journal·B LauenborgA Woetmann
Dec 16, 2017·Journal of Cutaneous Medicine and Surgery·Feras M GhazawiIvan V Litvinov
Oct 9, 2018·International Journal of Dermatology·Alejandra AbeldañoRoberto Chuit
Oct 17, 2018·Journal of Cutaneous Medicine and Surgery·Feras M Ghazawi, Ivan V Litvinov
Apr 3, 2020·Journal of Cutaneous Medicine and Surgery·Feras M GhazawiIvan V Litvinov
Jun 2, 2020·Frontiers in Oncology·Zaw H PhyoSima Rozati
Dec 21, 2016·Current Hematologic Malignancy Reports·Anh PhanMary Jo Lechowicz
Mar 18, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ivan V LitvinovThomas S Kupper
Jan 22, 2021·Journal of the American Academy of Dermatology·Stephen J MalachowskiLucia Seminario-Vidal
Nov 13, 2017·The Journal of Investigative Dermatology·Melania H FanokSergei B Koralov

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