Identification of GTP-binding proteins in myelin and oligodendrocyte membranes

Journal of Neuroscience Research
P E BraunL Bernier

Abstract

Myelin membranes purified from mouse and rat brain are associated with alpha subunits of four signal transducing guanosine triphosphate (GTP)-binding proteins: Go, Gi, Gs, and ras. Four low-molecular-weight (Mr) GTP-binding proteins are also present, as demonstrated by the binding of GTP to proteins immobilized in nitrocellulose. This latter group is more prominent at early stages of myelination and remains associated with isolated myelin membranes despite repetitive cycles of purification. At least one nonmyelin subcellular membrane fraction possesses the same proteins. The total membrane fraction of cultured oligodendrocytes is associated with both groups of GTP-binding proteins. None of the well-known myelin proteins bound GTP by the procedure described.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jan 1, 1987·Molecular and Cellular Endocrinology·A M Spiegel
May 16, 1988·Biochemical and Biophysical Research Communications·C K ChanM A Moscarello
Jan 1, 1989·Journal of Neuroscience Research·A M EdwardsP E Braun
Mar 31, 1989·Biochemical and Biophysical Research Communications·J G ComerfordI Gibson
Jun 23, 1989·Science·L S MayorgaP D Stahl
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·F A Ribeiro-Neto, M Rodbell
Aug 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E Santos, A R Nebreda
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·T Kamata, H F Kung
Jul 9, 1987·Nature·R D Burgoyne
Jan 1, 1987·Annual Review of Biochemistry·A G Gilman
Jul 15, 1987·The Biochemical Journal·R P Bhullar, R J Haslam
Jan 1, 1987·Annual Review of Biochemistry·M Barbacid
Feb 1, 1988·Journal of Neuroscience Research·V W YongS U Kim
Oct 1, 1973·Journal of Neurochemistry·W T Norton, S E Poduslo

❮ Previous
Next ❯

Citations

Aug 15, 1995·Journal of Neuroscience Research·H BabaW B Macklin
Sep 1, 1996·Journal of Lipid Mediators and Cell Signalling·J EichbergG DeVries
Dec 24, 1997·Brain Research. Molecular Brain Research·R BurcelinJ N Larocca
Oct 1, 1992·Neuropathology and Applied Neurobiology·R J Thompson
Nov 1, 1992·Journal of Neurochemistry·L N Berti-MatteraT Y Goraya
May 1, 1993·Journal of Neurochemistry·J N Larocca, R W Ledeen
Nov 1, 1993·Journal of Neurochemistry·G Chakraborty, R W Ledeen
Jul 1, 1991·Journal of Neurochemistry·J N LaroccaR W Ledeen
Nov 1, 1995·Neurochemical Research·C BouliasM A Moscarello
Mar 29, 2001·Microscopy Research and Technique·E M KrämerK A Nave
Nov 8, 2007·Chemical Biology & Drug Design·Stefania StingoMaurizio Bifulco
Jun 18, 2002·Journal of Neurochemistry·Christopher M TaylorSteven E Pfeiffer
Apr 1, 1996·Neurochemical Research·J Eichberg, S Iyer
Apr 1, 1996·Neurochemical Research·M GrabowR W Ledeen
Aug 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M T Filbin, G I Tennekoon
Apr 1, 1994·Journal of Neurochemistry·L Sepp-LorenzinoJ N Larocca
Mar 29, 2001·Physiological Reviews·N Baumann, D Pham-Dinh
Nov 19, 1997·Journal of Neuroscience Research·G ChakrabortyR W Ledeen
Jun 1, 1993·Glia·C H Kastritsis, K D McCarthy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.