Identification of high-grade serous ovarian cancer miRNA species associated with survival and drug response in patients receiving neoadjuvant chemotherapy: a retrospective longitudinal analysis using matched tumor biopsies

Annals of Oncology : Official Journal of the European Society for Medical Oncology
Marco PetrilloS Marchini

Abstract

Neoadjuvant chemotherapy (NACT) has been recognized as a reliable therapeutic strategy in patients with unresectable advanced epithelial ovarian cancer (EOC). The molecular events leading to platinum (Pt) response in NACT settings have hitherto not been explored. In the present work, longitudinal changes of miRNA expression profile were investigated to identify miRNA families with prognostic role in high-grade serous EOC patients who received the NACT regimen. One hundred sixty-four matched tumor biopsies taken at initial laparoscopic evaluation and at interval-debulking surgery (IDS) after four courses of Pt-based therapy were selected from 82 stage IIIC-IV high-grade serous-EOC patients that were judged unsuitable for complete primary debulking and subjected the NACT protocol. miRNA profiling by microarray, real-time PCR and immuno-histochemical staining for Smad2 phosphorylation (P-Smad2) were used for data analysis. Analysis revealed that 369 miRNAs were differentially expressed in matched biopsies (referred to as DEMs). DEMs were not scattered across the genome, but clustered into families: miR-199, let-7, miR-30, miR-181 and miR-29. Multivariate analysis showed that miR-199a-3p, miR-199a-5p, miR-181a-5p and let-7g-5p asso...Continue Reading

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Citations

Aug 2, 2017·International Journal of Molecular Sciences·Elisenda Alsina-SanchísFrancesc Viñals
Mar 24, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Leila KafshdoozSamaneh Ghasemali
Feb 14, 2019·Technology in Cancer Research & Treatment·Raúl García-VázquezCésar López-Camarillo
Jan 16, 2020·Cells·Cristina Elena StaicuSilviu-Cristian Voinea
Feb 26, 2020·International Journal of Cancer. Journal International Du Cancer·Giuseppe BenvenutoSergio Marchini
Jul 6, 2020·International Journal of Cancer. Journal International Du Cancer·Konstantina PanoutsopoulouAndreas Scorilas
Oct 5, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R RoatZ Guo
Jan 13, 2018·Cancer Metastasis Reviews·Cecilia Pop-BicaGeorge A Calin
Oct 2, 2019·International Journal of Molecular Sciences·Eros AzzaliniSerena Bonin
Apr 26, 2018·Molecular Medicine Reports·Yulin LaiLiangchao Ni
May 8, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Camilla NeroMarco Petrillo
Feb 11, 2021·Cancers·Ami PatelNicole D Fleming
Jul 22, 2021·Journal of Cellular and Molecular Medicine·Yuxian WuZhijun Jin
Aug 19, 2021·Cancer Cell International·Weiwei XieXipeng Wang

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