PMID: 8463731Jan 1, 1993Paper

Identification of high intraocular pressure responders to topical ophthalmic corticosteroids

Journal of Ocular Pharmacology
J D BartlettC M Adams

Abstract

To locate suitable candidates to study the intraocular pressure (IOP) effects of new ocular steroids, healthy volunteers must be challenged with topically applied steroids to verify that such individuals are indeed high "steroid responders"; that is, they respond with IOP elevations of at least 5 mmHg during a 4- to 6-week challenge with the topically applied steroid. We used first-degree offspring of individuals with primary open-angle glaucoma to develop a model to identify high steroid responders to topical ophthalmic prednisolone. We conducted a prospective, randomized, open-label, placebo-controlled study of prednisolone phosphate 1.0% in which 13 subjects received either topical prednisolone phosphate 4 times daily to the right eye and placebo to the left eye, or vice versa. Baseline evaluations occurred on study Day 0, and follow-up examinations were on Days 7, 14, 21, 28, 35, and 42. The medications were administered continuously for 6 weeks or until the IOP rose > or = 10 mmHg. After the effect of diurnal variation in IOP was taken into account, 4 of the 13 subjects (31%) had a maximum elevation in IOP of 4 mmHg or less, 7 subjects (54%) showed maximum elevations in IOP of 5 to 9 mmHg, and 2 subjects (15%) had a maximu...Continue Reading

References

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Citations

Dec 2, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·J S Seggev
Dec 2, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M S DuhA M Laties
Aug 7, 1999·Progress in Retinal and Eye Research·R J Wordinger, A F Clark
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Mar 11, 2008·Investigative Ophthalmology & Visual Science·Xinyu ZhangThomas Yorio
Mar 10, 2010·Expert Opinion on Pharmacotherapy·Timothy L Comstock, Edward J Holland
Oct 6, 2011·Journal of Refractive Surgery·Kraig S BowerKeith J Wroblewski
Jul 22, 2008·American Journal of Ophthalmology·Ling-Ing LauWen-Ming Hsu
Jun 9, 2015·Experimental Eye Research·Darryl R Overby, Abbot F Clark
Sep 1, 2005·Journal of Cataract and Refractive Surgery·James P Gills, Pit Gills
Jun 15, 2007·Current Medical Research and Opinion·Mark KramarYu-Guang He
Jul 9, 2016·European Journal of Pharmacology·Adnan Dibas, Thomas Yorio
Aug 28, 2016·Drugs & Aging·Beatriz AbadiaLuis Pablo
Sep 27, 2016·Progress in Retinal and Eye Research·M Elizabeth FiniW Daniel Stamer
Jan 11, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Gail TorkildsenFrancis S Mah
Jan 6, 2006·International Journal of Toxicology·David H McGeeMargarita M Gruebbel
Nov 18, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T SengokuS Mutoh
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Jun 1, 2008·Clinical Ophthalmology·Pier E Gallenga, Lucio Lobefalo
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Oct 22, 2020·Journal of Cataract and Refractive Surgery·Jesper H ErichsenLine Kessel
Feb 15, 2019·American Journal of Ophthalmology·Weilin ChanLucia Sobrin

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