Identification of HTA as a novel-specific marker for human hepatocellular carcinoma.

Journal of Cancer Research and Clinical Oncology
Yan LiuGuancheng Li

Abstract

Hepatocellular carcinoma (HCC) is the most common malignancy in the world, especially in China. Early diagnosis of new and recurrent hepatocellular carcinoma, followed by timely treatment, will help decrease mortality. Currently biomarkers are not satisfactory. Better diagnostic methods are highly demanded. In this study, we have used in silico identification and RT-PCR test and discovered a hepatoma associated gene (HTA). Knockdown of endogenous HTA expression was performed by small interfering RNA in malignant hepatocyte HepG2. Then we tested the cell proliferative ability of these cells in vitro and in vivo. HTA was expressed specifically in some kinds of tumors, but not detected in any normal tissues. It was expressed especially high in hepatocellular carcinoma. Knockdown of endogenous HTA expression in HepG2 by small interfering RNA attenuated HCC cell growth. HCA is a very good marker for tumors, especially for HCC. It could play important roles in HCC development and progression and can be a promising molecular target for the development of new diagnostic and therapeutic strategies for HCC.

References

Dec 16, 1998·Nature Biotechnology·Z Szallasi
Mar 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shahrokh F ShariatKevin M Slawin
Jan 28, 2004·Cancer Letters·Evgeny N ImyanitovKaido P Hanson
Oct 28, 2004·Gastroenterology·Hashem B El-Serag
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Mar 9, 2005·Cancer Research·Eduardo M ReisUNKNOWN Head and Neck Annotation Consortium
Aug 31, 2006·Expert Opinion on Emerging Drugs·Lewis R Roberts, Gregory J Gores
Jul 10, 2007·The American Journal of Gastroenterology·Richard K SterlingMyron E Schwartz

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Citations

Nov 12, 2013·Pathology Oncology Research : POR·Yanhong LiuGuancheng Li
Apr 14, 2016·Epigenomics·Michael SandSchapoor Hessam
Oct 15, 2013·American Journal of Clinical Pathology·Bing RenWenqing Cao
Mar 22, 2014·Molecular and Clinical Oncology·Yan-Jie ZhaoGuan-Cheng Li
Jan 15, 2013·International Journal of Oncology·Yanhong LiuYuehui Li

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