Identification of HTLV-I sequence in cord blood mononuclear cells of neonates born to HTLV-I antigen/antibody-positive mothers by polymerase chain reaction

Japanese Journal of Cancer Research : Gann
S SaitoM Ichijo

Abstract

We developed a polymerase chain reaction (PCR) method which has high sensitivity and simple technique in order to investigate the presence or absence of human T lymphotropic virus type I (HTLV-I) provirus in cord blood mononuclear cells of neonates born to HTLV-I carrier mothers. Out of 40, three subjects were found to contain the HTLV-I provirus genome. These three subjects remained HTLV-I sequence-positive in follow-up study. On the other hand, when examined by a conventional technique for detection of HTLV-I-associated antigen on peripheral mononuclear cells, all 40 neonates were HTLV-I-associated antigen-negative. These results suggest that PCR is more sensitive than the conventional antigen detection method and is useful in early detection of HTLV-I infection in neonates born to HTLV-I carriers.

References

Jul 1, 1989·The Journal of Infection·Y AndoT Toyama
Nov 16, 1985·Lancet·E JovaisasD Löwenthal
May 3, 1986·Lancet·M OsameM Tara
Jan 29, 1983·Lancet·A KomuroM Hirayama
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M SeikiM Yoshida
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·Y HinumaI Miyoshi

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Citations

Dec 1, 1993·Annals of Hematology·E J AlJ G Huisman
Feb 1, 1992·Lancet·I MiyoshiY Tanaka
Aug 5, 2000·Journal of Reproductive Immunology·T Fujino, Y Nagata
Oct 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vandack NobreUNKNOWN GIPH Interdisciplinary Group on HTLV-1/2 Research
Apr 1, 1993·Acta Paediatrica Japonica; Overseas Edition·M Narita
Nov 7, 1992·Lancet·T FujinoY Nagata
Jan 7, 1999·Revista Do Instituto De Medicina Tropical De São Paulo·A L Bittencourt
Sep 1, 1993·AIDS Research and Human Retroviruses·N MonplaisirL Gazzolo
Nov 18, 2000·AIDS Research and Human Retroviruses·M KannagiT Yoshiki
Jan 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·S HinoT Miyamoto
May 28, 2019·Frontiers in Microbiology·Carolina Rosadas, Graham P Taylor
Feb 20, 2007·Revista Da Sociedade Brasileira De Medicina Tropical·Bruna Pedroso Tamegão-LopesJosé Alexandre Rodrigues de Lemos
Oct 20, 2020·The Journal of Clinical Investigation·Kenta TezukaIsao Hamaguchi

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