Identification of hub genes and pathways in adrenocortical carcinoma by integrated bioinformatic analysis.

Journal of Cellular and Molecular Medicine
Jinshuai GuoXiangqian Guo

Abstract

Adrenocortical carcinoma (ACC), a rare malignant neoplasm originating from adrenal cortical cells, has high malignancy and few treatments. Therefore, it is necessary to explore the molecular mechanism of tumorigenesis, screen and verify potential biomarkers, which will provide new clues for the treatment and diagnosis of ACC. In this paper, three gene expression profiles (GSE10927, GSE12368 and GSE90713) were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were obtained using the Limma package. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were enriched by DAVID. Protein-protein interaction (PPI) network was evaluated by STRING database, and PPI network was constructed by Cytoscape. Finally, GEPIA was used to validate hub genes' expression. Compared with normal adrenal tissues, 74 up-regulated DEGs and 126 down-regulated DEGs were found in ACC samples; GO analysis showed that up-regulated DEGs were enriched in organelle fission, nuclear division, spindle, et al, while down-regulated DEGs were enriched in angiogenesis, proteinaceous extracellular matrix and growth factor activity; KEGG pathway analysis showed that up-regulated DEGs were significan...Continue Reading

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Citations

Oct 10, 2020·World Journal of Clinical Oncology·Dumitru Andrei Iacobas
Nov 25, 2020·Journal of Cellular and Molecular Medicine·Meng-Xi XiuWen-Jun Wang

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Datasets Mentioned

BETA
GSE12368
GSE90713
GSE10927

Methods Mentioned

BETA
surgical resection
RNAseq
GTPase

Software Mentioned

R
Xena browser
Search Tool for the Retrieval
SPSS
Limma
DAVID
GEPIA
Cytoscape

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex, associated with a generally dismal prognosis owing to its aggressive behavior. Here are the latest discoveries pertaining to this disease.