Identification of hub genes associated with adult acute myeloid leukemia progression through weighted gene co-expression network analysis.

Aging
Ruiqi ZhuYu Hu

Abstract

Acute myeloid leukemia (AML) is a malignancy of hematopoietic stem cells. Although many candidate genes such as CEBPA, FLT3, IDH1, and IDH2 have been associated with AML initiation and prognosis, the molecular mechanisms underlying this disease remain unclear. In this study, we used a systemic co-expression analysis method, namely weighted gene co-expression network analysis (WGCNA), to identify new candidate genes associated with adult AML progression and prognosis. We identified around 5,138 differentially expressed genes (DEGs) between AML samples (from The Cancer Genome Atlas database) and normal control samples (from the Genotype-Tissue Expression database). WGCNA identified nine co-expression modules with significant differences based on the DEGs. Among modules, the turquoise and blue ones were the most relevant to AML (P-value: turquoise 0, blue 4.64E-77). GO term and KEGG pathway analyses revealed that pathways that are commonly dysregulated in AML were all enriched in the blue and turquoise modules. A total of 15 hub genes were identified to be crucial for AML progression. PIVOT analysis revealed non-coding RNAs, transcriptional factors, and drugs associated with the hub genes. Finally, survival analysis revealed that ...Continue Reading

References

Dec 21, 2004·Nucleic Acids Research·Ada HamoshVictor A McKusick
Oct 16, 2007·Oncogene·T Pabst, B U Mueller
Jul 9, 2008·Cellular Oncology : the Official Journal of the International Society for Cellular Oncology·C J HessQ Waisfisz
Dec 31, 2008·BMC Bioinformatics·Peter Langfelder, Steve Horvath
Oct 1, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Serengulam V GovindanDavid M Goldenberg
May 5, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claire L GreenRosemary E Gale
Jun 18, 2010·Genes and Immunity·UNKNOWN International Multiple Sclerosis Genetics Conssortium (IMSGC)
Aug 9, 2011·International Journal of Cancer. Journal International Du Cancer·Eirikur SaelandYvette van Kooyk
Jan 11, 2012·Leukemia Research·Natalie PutPeter Vandenberghe
May 30, 2013·Nature Genetics·UNKNOWN GTEx Consortium
Feb 19, 2015·Contemporary Oncology Współczesna Onkologia·Katarzyna TomczakMaciej Wiznerowicz
Aug 21, 2016·Mutation Research. Reviews in Mutation Research·Bani Bandana Ganguly, N N Kadam
Sep 15, 2016·Science Signaling·Laure DavidJean-Sébastien Hoffmann
Jun 25, 2017·Chemico-biological Interactions·Maura Gasparetto, Clayton A Smith
Jun 19, 2018·International Journal of Biological Sciences·Qingguo LiSanjun Cai
Jul 20, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tian-Hui YangJeffrey J Molldrem
Dec 12, 2018·Breast Cancer Research and Treatment·Xi-Mei WangChunhua Xiao
Oct 28, 2019·Cell Death & Disease·Chang BaoWeimin Fan

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