PMID: 1194827Oct 1, 1975Paper

Identification of human luteinizing hormone, follicle-stimulating hormone, luteinizing hormone beta-subunit and gonadotrophin alpha-subunit in foetal and adult pituitary glands

The Journal of Endocrinology
C Hagen, A S McNeilly

Abstract

Specific radioimmunoassays were used to assess the content of LH, FSH, the gonadotrophin alpha-subunit and the LH beta-subunit in four adult, 19 normal foetal pituitary glands (9-5--32 weeks of gestation) and a pituitary extract from an anencephalic foetus (36 weeks). The hormones and subunits were further identified by column chromatography on Sephadex G-100. All pituitary glands contained free alpha-subunit and intact LH but the alpha-subunit:LH ratio was significantly higher in the early foetal pituitaries (9-5--16 weeks) than in the four adult pituitaries. Only small or undetectable amounts of LH beta-subunit and 'undetectable' FSH were found in these early foetal pituitaries (9-5--11-5 weeks). The concentration of intact hormones or subunits in the pituitaries showed no significant sex difference in any of the groups. In contrast to these results, only alpha-subunit was detectable in the pituitary of the anencephalic foetus. For 14 early foetuses (age of gestation 10--16 weeks) the serum levels of LH-HCG, FSH, and alpha-subunit in the circulation were significantly higher than in 26 foetuses at term (37--41 weeks). On the basis of these results a theory for the development of the gonadotrophin secretion from the foetal pit...Continue Reading

Citations

Sep 1, 1991·Journal of Electron Microscopy Technique·P M Dubois, F J Hemming
May 1, 1977·Journal of Steroid Biochemistry·C Hagen, A S McNeilly
Nov 1, 1977·Molecular and Cellular Endocrinology·J L PasteelsP Franchimont
May 1, 1984·Molecular and Cellular Endocrinology·H E GrotjanB A Keel
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·I A Kourides, B D Weintraub
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·N C Vamvakopoulos, I A Kourides
Mar 1, 1977·The Journal of Clinical Investigation·I A KouridesF Maloof
Oct 20, 2009·The Journal of Clinical Endocrinology and Metabolism·Paul A FowlerPeter J O'Shaughnessy
Jan 1, 1977·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·C Hagen
Feb 1, 1996·Journal of Neuroendocrinology·A Van Bael, C Denef
Nov 1, 1978·Clinics in Endocrinology and Metabolism·H PetersJ Grinsted
Nov 15, 1997·Microscopy Research and Technique·P M DuboisA G Héritier
Jun 30, 2006·Developmental Biology·Caroline PopeAlan S McNeilly
Sep 18, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Taruna AroraKambadur Muralidhar

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