Identification of human placenta-derived mesenchymal stem cells involved in re-endothelialization

Journal of Cellular Physiology
Tu Cam TranOsamu Ohneda

Abstract

Human placenta is an attractive source of mesenchymal stem cells (MSC) for regenerative medicine. The cell surface markers expressed on MSC have been proposed as useful tools for the isolation of MSC from other cell populations. However, the correlation between the expression of MSC markers and the ability to support tissue regeneration in vivo has not been well examined. Here, we established several MSC lines from human placenta and examined the expression of their cell surface markers and their ability to differentiate toward mesenchymal cell lineages. We found that the expression of CD349/frizzled-9, a receptor for Wnt ligands, was positive in placenta-derived MSC. So, we isolated CD349-negative and -positive fractions from an MSC line and examined how successfully cell engraftment repaired fractured bone and recovered blood flow in ischemic regions using mouse models. CD349-negative and -positive cells displayed a similar expression pattern of cell surface markers and facilitated the repair of fractured bone in transplantation experiments in mice. Interestingly, CD349-negative, but not CD349-positive cells, showed significant effects on recovering blood flow following vascular occlusion. We found that induction of PDGFβ and...Continue Reading

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Citations

Jun 18, 2011·Frontiers of Medicine·Ranhua JiangZhong Chao Han
May 29, 2012·Journal of Molecular Neuroscience : MN·Yonit Fisher-ShovalDaniel Offen
Jan 23, 2013·Stem Cells and Development·Raquel CalloniDiego Bonatto
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Aug 9, 2019·BioMed Research International·V ShabliiG Lobyntseva
Feb 5, 2021·Frontiers in Cell and Developmental Biology·Seley GharaneiBee Kang Tan

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