Identification of hypertrophy- and heart failure-associated genes by combining in vitro and in vivo models

Physiological Genomics
Bo LuHerman H W Silljé

Abstract

Heart failure (HF) is a complex disease involving multiple changes including cardiomyocyte hypertrophy (growth). Here we performed a set of screens in different HF and hypertrophy models to identify differentially expressed genes associated with HF and/or hypertrophy. Hypertensive Ren2 rats and animals with postmyocardial infarction (post-MI) HF were used as in vivo HF models, and neonatal rat cardiomyocytes treated with hypertrophy inducing hormones phenylephrine, endothelin-1, and isoproterenol were used as in vitro models. This combined approach revealed a robust set of genes that were differentially expressed both in vitro and in vivo. This included known genes like NPPA (ANP) and FHL1, but also novel genes not previously associated with hypertrophy/HF. Among these are PTGIS, AKIP1, and Dhrs7c, which could constitute interesting targets for further investigations. We also identified a number of in vivo specific genes and these appeared to be enriched for fibrosis, wounding, and stress responses. Therefore a number of novel genes within this in vivo specific list could be related to fibroblasts or other noncardiomyocytes present in the heart. We also observed strong differences between the two HF rat models. For example KCNE...Continue Reading

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Citations

Jan 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mira SastriSusan S Taylor
Oct 31, 2013·International Journal of Molecular Sciences·Hongjuan YuHerman H W Silljé
Apr 21, 2016·Journal of Molecular and Cellular Cardiology·Wardit TigchelaarHerman H W Silljé
Jul 16, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Wardit TigchelaarHerman H W Silljé
Nov 4, 2016·American Journal of Physiology. Cell Physiology·Shinobu AraiHiroyuki Tsutsui
Feb 18, 2016·Heart Failure Reviews·A PiekH H W Silljé
Nov 10, 2017·Journal of Muscle Research and Cell Motility·Mehroz EhsanKatja Gehmlich
Apr 12, 2017·Biomicrofluidics·Bradley W EllisPinar Zorlutuna
Nov 8, 2014·American Journal of Physiology. Cell Physiology·Wardit TigchelaarHerman H W Silljé
May 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Caitlin S WyrwollMegan C Holmes
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Apr 20, 2021·Frontiers in Cardiovascular Medicine·Celina MadjeneBenjamin Richard
Dec 28, 2021·European Journal of Heart Failure·Kirsten T NijholtB Daan Westenbrink

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