PMID: 6984189Dec 1, 1982Paper

Identification of idiotypic receptors on reovirus-specific cytolytic T cells

Proceedings of the National Academy of Sciences of the United States of America
H C ErtlR W Finberg

Abstract

Cytolytic T lymphocytes (Tc) specific for cells infected with reovirus type 3 were shown to lyse an uninfected B-cell hybridoma line (designated 87.92.6). This hybridoma expresses and secretes an anti-idiotypic antibody that reacts with a monoclonal antibody (termed G-5). G-5 recognizes a domain on the hemagglutinin of the reovirus that is relevant to virus tropism. The Tc cell response was H-2 restricted and could be inhibited by G-5. As shown by limiting dilution analysis, identical clones lysed reovirus-infected and anti-idiotype-bearing target cells. Tc cells induced by a variant of wild-type reovirus type 3 (immunologically selected by resistance to neutralization by G-5) were unable to recognize the anti-idiotype-bearing cells although they lysed reovirus type 3-infected tumor cells. We conclude that Tc cells must bear determinants that bind anti-idiotype molecules and, furthermore, that B cells and cytolytic T cells can share these idiotypic determinants.

References

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R FinbergS J Burakoff
Jan 1, 1979·Journal of Immunological Methods·H C ErtlU H Koszinowski
Jan 1, 1980·Immunological Reviews·H R MacDonaldK T Brunner
Oct 1, 1981·The Australian Journal of Experimental Biology and Medical Science·H C Ertl
Nov 1, 1981·The Journal of Experimental Medicine·Y N LiuJ L Schulman
Oct 1, 1975·European Journal of Immunology·K Eichmann, K Rajewsky

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Citations

Jan 1, 1987·Cancer Metastasis Reviews·G T Nepom, K E Hellström
Jan 1, 1989·Archives of Virology·A NathJ S Wolinsky
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Sep 2, 2008·Biochimica Et Biophysica Acta·Haeman JangRichard Jay Smeyne
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Oct 1, 1984·Immunological Reviews·D W LanckiF W Fitch
Apr 1, 1986·Immunological Reviews·R W Finberg, H C Ertl
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Oct 15, 1983·International Journal of Cancer. Journal International Du Cancer·H BinzH Wigzell

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