PMID: 22329520Feb 15, 2012Paper

Identification of IL7RA risk alleles for rapid progression during HIV-1 infection: a comprehensive study in the GRIV cohort

Current HIV Research
Sophie LimouJean-François Zagury

Abstract

Interleukin 7 (IL7) is a critical factor for lymphocyte homeostasis. A dysfunction of the IL7/IL7R pathway has previously been described in HIV-1 infection, and promising results were observed in recent analyses of IL7 for therapeutic use in HIV infected individuals. However, further investigations are still warranted to understand the possible roles of this cytokine. Here, we explored whether the IL7 and IL7RA genetic polymorphisms were associated with the progression of HIV infection. We extensively genotyped the IL7 and IL7RA genes in the GRIV (Genomics of Resistance to Immunodeficiency Virus) cohort, composed of patients with extreme progression profiles - long-term non (LTNP) and rapid (RP) progressors--, and in a healthy control group (CTR). Statistical case-control analyses were performed using the Fisher's exact test, comparing either LTNP vs CTR or RP vs CTR. Three IL7RA SNPs (single nucleotide polymorphisms--rs7701176, rs987106 and rs10491434), but no IL7 SNPs, were significantly associated with rapid disease progression (P < 0.01). In a multi-marker analysis focusing on functional variants, a strong association between an IL7RA haplotype and rapid progression was observed (P = 5.59 x 10(-3)). In summary, our comprehe...Continue Reading

Citations

Sep 25, 2015·European Journal of Clinical Investigation·María Guzmán-FulgencioSalvador Resino
Jul 1, 2015·Journal of Translational Medicine·María Guzmán-FulgencioSalvador Resino
Sep 23, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M Guzmán-FulgencioS Resino
Jun 19, 2019·Biomolecules·Salvador ResinoUNKNOWN CoRIS and the HIV Biobank integrated in the Spanish AIDS Research Network Project RIS/EPICLIN 10_2015
Aug 24, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mehwish YounasYves Lévy
Aug 11, 2017·European Journal of Clinical Investigation·Luz María MedranoSalvador Resino

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