Identification of immune parameters to differentiate disease states among sheep infected with Mycobacterium avium subsp. paratuberculosis.

Clinical and Vaccine Immunology : CVI
Sonia GillanJ Frank T Griffin

Abstract

Johne's disease, a chronic enteritis of ruminants, is caused by infection with Mycobacterium avium subsp. paratuberculosis. Three distinct forms have been observed in sheep: paucibacillary disease (PB), multibacillary disease (MB), and asymptomatic infection (AS). In this study, immune parameters for animals naturally infected with M. avium subsp. paratuberculosis and identified postmortem as having PB, MB, or AS were compared to provide a further understanding of the immunological reactivity contributing to or resulting from these different disease states in sheep. PB was associated with strong ex vivo M. avium subsp. paratuberculosis antigen-stimulated gamma interferon responses, pronounced increases in CD25(+) T-cell frequencies in circulation, antibody production, and a B-cell population that expanded significantly upon ex vivo antigenic stimulation. The MB group featured the highest antibody levels and a lack of cellular immune responsiveness to the M. avium subsp. paratuberculosis antigen. The AS group expressed an immunological phenotype intermediate between that for noninfected control animals and that for the PB group. The relationship between immune responses and disease severity within the PB group was investigated m...Continue Reading

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Citations

Jan 14, 2011·Clinical and Vaccine Immunology : CVI·J R Stabel, S Robbe-Austerman
Nov 5, 2010·Veterinary Immunology and Immunopathology·John P Bannantine, Adel M Talaat
Aug 11, 2015·Veterinary Microbiology·P A Windsor
Apr 1, 2011·Veterinary Immunology and Immunopathology·Richard J WhittingtonAuriol C Purdie
Feb 19, 2019·Australian Veterinary Journal·P J HodgeA H Noormohammadi
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Palazzo FiorentinaGiulietta Minozzi

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