Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma

PloS One
Lluc Farrera-SolerNicolas Winssinger


A novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) is the source of a current pandemic (COVID-19) with devastating consequences in public health and economic stability. Using a peptide array to map the antibody response of plasma from healing patients (12) and heathy patients (6), we identified three immunodominant linear epitopes, two of which correspond to key proteolytic sites on the spike protein (S1/S2 and S2') known to be critical for cellular entry. We show biochemical evidence that plasma positive for the epitope adjacent to the S1/S2 cleavage site inhibits furin-mediated proteolysis of spike.


Sep 21, 2000·Antiviral Research·L A Sawyer
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuxian HeShibo Jiang
Jul 23, 2005·Chemistry : a European Journal·Jennifer L Harris, Nicolas Winssinger
Jan 27, 2015·Current Opinion in Chemical Biology·Claudio ZambaldoNicolas Winssinger
Apr 13, 2019·Nucleic Acids Research·Fábio MadeiraRodrigo Lopez
Sep 8, 2019·Viruses·Entedar A J AlsaadiIan M Jones
Dec 6, 2019·Journal of Virology·Vineet D MenacheryRalph S Baric
Jan 18, 2020·Science·Jon Cohen, Dennis Normile
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Mar 11, 2020·Cell·Alexandra C WallsDavid Veesler
Apr 7, 2020·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Qingqing LinLiangshun You
Apr 20, 2020·International Journal of Surgery·Maria NicolaRiaz Agha
May 6, 2020·Nature Communications·Chunyan WangBerend-Jan Bosch
May 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jian ShangFang Li
May 10, 2020·Science·Barney S Graham
May 16, 2020·Cell Host & Microbe·Yanling WuTianlei Ying

❮ Previous
Next ❯


Dec 9, 2020·Molecular Ecology·Diego ForniManuela Sironi
Apr 10, 2021·Frontiers in Immunology·Tatjana SchwarzVictor M Corman
Apr 24, 2021·Drug Discovery Today·Long-Can MeiGuang-Fu Yang
May 15, 2021·Current Opinion in Virology·Ana P Valente, Mariana Manzano-Rendeiro
Apr 4, 2021·ChemMedChem·Marcus J C Long, Yimon Aye
Jul 4, 2021·Bioorganic & Medicinal Chemistry·Jean-Pierre DaguerNicolas Winssinger
Jul 9, 2021·Proceedings of the National Academy of Sciences of the United States of America·Daniela I StaquiciniRenata Pasqualini
Jul 18, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Tomoyuki YamaguchiHidemitsu Nakagawa
Jul 30, 2021·European Journal of Clinical Investigation·Sabrina PaganoNicolas Vuilleumier
Sep 10, 2021·PloS One·Adam V WisnewskiJohn C Shon
Oct 14, 2021·Nucleic Acids Research·Mercy RophinaVinod Scaria

❮ Previous
Next ❯

Methods Mentioned

Enzyme-Linked Immunosorbent Assay
peptide array
confocal microscopy

Software Mentioned


Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.