Identification of inducing, responding, and suppressing regions in an experimental model of notochord formation in avian embryos

Developmental Biology
S YuanG C Schoenwolf

Abstract

The notochord normally arises from committed cells in the rostral tip of the primitive streak. After removal of these cells from the avian gastrula, embryos with notochords nevertheless develop in the majority of cases. A region required for the formation of this reconstituted notochord lies lateral to the primitive streak. In the present study we have determined that this region acts as an inducer for more lateral cells in the epiblast, which actually give rise to the reconstituted notochord. The strongest inducing region lies between 0-250 micrometer lateral to the streak and 500-750 micrometer caudal to the rostral end of the streak and chiefly contains cells normally fated to form lateral plate and somitic mesoderm. The responding region is located 250-500 micrometer lateral to the streak and 0-750 micrometer caudal to the rostral end of the streak. This area chiefly contains cells normally fated to form neural ectoderm, although cells normally fated to form lateral plate and somitic mesoderm are also within this area. The inducing and responding areas interact to form reconstituted notochord either when the primitive streak, including its rostral end (Hensen's node), is removed from the cultured blastoderm or when the indu...Continue Reading

Citations

Dec 8, 1998·Developmental Genetics·H J Yost
Nov 19, 1997·Trends in Neurosciences·J L Smith, G C Schoenwolf
Nov 1, 2001·Annual Review of Cell and Developmental Biology·M Mercola, M Levin
Nov 5, 1997·Mechanisms of Development·L Lemaire, M Kessel
Feb 12, 1998·Mechanisms of Development·P P Tam, R R Behringer
May 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D K Darnell, G C Schoenwolf
Oct 23, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K H HealyD K Darnell
Nov 18, 2000·Annals of the New York Academy of Sciences·G C Schoenwolf

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