Identification of influencing variables on adiponectin serum levels in diabetes mellitus type 1 and type 2

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
A SchäfflerB Zietz

Abstract

Adiponectin represents an adipocyte-specific secretory protein that has been discussed recently as candidate gene and promising new drug target to restore insulin sensitivity in diabetes mellitus type 2. The aim of the present study was to define influencing variables on adiponectin serum levels in a large cohort of caucasian patients with type 1/type 2 diabetes and healthy controls. Additionally, adiponectin gene polymorphisms (Tyr111His and Gly15Gly) were investigated for possible associations with adiponectin serum levels. Adiponectin serum concentrations were measured in a metabolically well characterized cohort of 892 caucasian patients (556 with type 2 diabetes, 118 with type 1 diabetes, 218 controls) by ELISA. Gene polymorphisms were determined by PCR-based RFLP. 1) Adiponectin values are dependent on gender with higher levels in diabetic females than in diabetic males. This gender-specific effect was only restricted to patients with diabetes and cannot be observed in controls. 2) In contrast to previous studies, the presence of diabetes does not influence adiponectin serum levels after correction for BMI. In addition, age has no influence on adiponectin levels. 3) Adiponectin levels are dependent on renal function at a ...Continue Reading

Citations

Mar 9, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y SheuJ A Cauley
Mar 3, 2007·Zeitschrift für Rheumatologie·E NeumannU Müller-Ladner
Nov 30, 2006·Reviews in Endocrine & Metabolic Disorders·Milagros Gloria Huerta
Feb 14, 2007·Journal of Gastroenterology and Hepatology·Andreas SchäfflerHans Herfarth
Nov 24, 2006·Clinical Endocrinology·Torbjörn LindströmHans J Arnqvist
May 16, 2009·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Lin-Chau ChangWei-Shiung Yang
Jun 13, 2008·Pediatric Diabetes·UNKNOWN Diabetes Research in Children Network (DirecNet) Study Group
Feb 22, 2011·Arthritis and Rheumatism·E NeumannU Müller-Ladner
Jun 29, 2005·Diabetes Care·Christophe E M De BlockLuc F Van Gaal
Jul 3, 2013·ISRN Oncology·Maria E Ramos-Nino
Jun 29, 2006·The Journal of Clinical Endocrinology and Metabolism·Samyah ShadidMichael D Jensen
Nov 26, 2009·Scandinavian Journal of Clinical and Laboratory Investigation·Ghorban Mohammadzadeh, Nosratollah Zarghami
Jul 14, 2017·Archives of Dermatological Research·Ming-Yue ZhangDong-Qing Ye
Sep 17, 2005·Kidney International·Brad H RovinHaikady N Nagaraja

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