Identification of Inhibitory Premotor Interneurons Activated at a Late Phase in a Motor Cycle during Drosophila Larval Locomotion

PloS One
Yuki ItakuraAkinao Nose

Abstract

Rhythmic motor patterns underlying many types of locomotion are thought to be produced by central pattern generators (CPGs). Our knowledge of how CPG networks generate motor patterns in complex nervous systems remains incomplete, despite decades of work in a variety of model organisms. Substrate borne locomotion in Drosophila larvae is driven by waves of muscular contraction that propagate through multiple body segments. We use the motor circuitry underlying crawling in larval Drosophila as a model to try to understand how segmentally coordinated rhythmic motor patterns are generated. Whereas muscles, motoneurons and sensory neurons have been well investigated in this system, far less is known about the identities and function of interneurons. Our recent study identified a class of glutamatergic premotor interneurons, PMSIs (period-positive median segmental interneurons), that regulate the speed of locomotion. Here, we report on the identification of a distinct class of glutamatergic premotor interneurons called Glutamatergic Ventro-Lateral Interneurons (GVLIs). We used calcium imaging to search for interneurons that show rhythmic activity and identified GVLIs as interneurons showing wave-like activity during peristalsis. Paire...Continue Reading

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Citations

Feb 28, 2019·Neuroscience Bulletin·Caixia GongZhefeng Gong
Jul 6, 2019·PLoS Computational Biology·Jane LovelessBarbara Webb
Jun 8, 2019·Journal of Neurogenetics·Youngteak YoonAkinao Nose
Mar 5, 2020·Developmental Neurobiology·Charalampos MantziarisAnsgar Büschges
Feb 15, 2018·Proceedings of the National Academy of Sciences of the United States of America·Swetha B M GowdaK VijayRaghavan
Apr 21, 2018·Neural Development·Matthew Q ClarkChris Q Doe

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