PMID: 7527167Dec 1, 1994Paper

Identification of insignificant prostate cancers: analysis of preoperative parameters

Urology
M B Irwin, J G Trapasso

Abstract

Analyzing preoperative parameters to help determine the risk of a random or systematic prostate needle biopsy specimen detecting an incidental microscopic prostate cancer. We reviewed the charts of 28 patients who had < or = 3 mm of Gleason grade (Glgr) < or = 2 (score < or = 4) prostate cancer in their prostate biopsy specimen and subsequently underwent a radical retropubic prostatectomy (RRP). Histopathologic review of the RRP specimen was carefully performed to determine the respective tumor volume, number of tumor foci, pathologic stage, Glgr, and score. Prostate-specific antigen (PSA) levels and the calculated PSA density (PSAD) were recorded for each case. Sixteen of the 28 (57%) RRP specimens contained a very small well-differentiated tumor (< or = 0.2 cc); 7 (25%) tumors were minimally larger (0.2 to 0.5 cc); and 2 specimens (7%) contained a large tumor (4 and 6 cc) only sampled by the biopsy specimen. Mean PSA levels and PSAD values both significantly differentiated tumors < or = 0.5 cc from those > 0.5 cc (p < 0.005). PSA < or = 4 vs PSAD < or = 0.1 correctly identified 12 of 23 (52%) vs 22 of 23 (96%) tumors < or = 0.5 cc, and 10 of 16 (63%) vs 15 of 16 (94%) tumors < or = 0.2 cc, respectively; both parameters exclud...Continue Reading

References

Nov 15, 1977·International Journal of Cancer. Journal International Du Cancer·N BreslowH Tulinius
Jan 11, 1986·Lancet·J E McNealT A Stamey
Jun 1, 1988·The Journal of Urology·T A StameyE Redwine
May 1, 1973·Journal of the National Cancer Institute·K Akazaki, G N Stemmerman
Jan 1, 1983·Journal of Cancer Research and Clinical Oncology·G Dhom
Jun 15, 1982·International Journal of Cancer. Journal International Du Cancer·R YataniP Correa

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Citations

Jan 17, 1996·International Journal of Cancer. Journal International Du Cancer·F H ShröderB G Blijenberg
Aug 11, 2000·Pathology Oncology Research : POR·J SzabóB Szende
Oct 6, 2005·Der Urologe. Ausg. A·M GraefenH Huland
Feb 15, 2008·Der Urologe. Ausg. A·M GraefenH Huland
Aug 15, 2006·Current Treatment Options in Oncology·Laurence Klotz
May 9, 2003·The Urologic Clinics of North America·David G BostwickCory Schlesinger
Apr 30, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Liang ChengMichael O Koch
Nov 27, 2007·Nature Clinical Practice. Oncology·Laurence Klotz
Mar 28, 2007·Prostate Cancer and Prostatic Diseases·P A S JohnstoneV Master
Jul 17, 1998·British Journal of Urology·T A GardnerJ Steckel
Sep 11, 2002·American Journal of Clinical Pathology·James S LewisPeter A Humphrey
Jul 23, 2008·Asian Journal of Andrology·Xiao-Dong JinBai-Ye Jin
May 24, 2011·European Urology·Guillaume PloussardTheodorus H van der Kwast
Sep 2, 2008·Surgical Oncology·Riccardo AutorinoRodolfo Montironi
Dec 19, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·O BettendorfA Semjonow
Feb 13, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Takashi OhigashiMototsugu Oya
Dec 31, 1998·Annals of Diagnostic Pathology·D G Bostwick, K A Iczkowski
Sep 1, 1997·The Journal of Urology·G J O'DowdJ E Oesterling
Nov 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laurence Klotz

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