Identification of intestinal flora-related key genes and therapeutic drugs in colorectal cancer.

BMC Medical Genomics
Jiayu ZhangTiancheng Zhao

Abstract

Colorectal cancer (CRC) is a multifactorial tumor and a leading cause of cancer-specific deaths worldwide. Recent research has shown that the alteration of intestinal flora contributes to the development of CRC. However, the molecular mechanism by which intestinal flora influences the pathogenesis of CRC remains unclear. This study aims to explore the key genes underlying the effect of intestinal flora on CRC and therapeutic drugs for CRC. Intestinal flora-related genes were determined using text mining. Based on The Cancer Genome Atlas database, differentially expressed genes (DEGs) between CRC and normal samples were identified with the limma package of the R software. Then, the intersection of the two gene sets was selected for enrichment analyses using the tool Database for Annotation, Visualization and Integrated Discovery. Protein interaction network analysis was performed for identifying the key genes using STRING and Cytoscape. The correlation of the key genes with overall survival of CRC patients was analyzed. Finally, the key genes were queried against the Drug-Gene Interaction database to find drug candidates for treating CRC. 518 genes associated with intestinal flora were determined by text mining. Based on The Can...Continue Reading

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Citations

Jul 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liguo JinXiaolei Wang

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Software Mentioned

VennDiagram
Expression Profiling Interactive Analysis ( GEPIA )
GEPIA
Cytoscape
MCODE
Molecular Complex Detection ( MCODE
STRING
limma
R
Database for Annotation , Visualization and Integrated Discove...

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